摘要
在体外对人直肠腺癌细胞株HR-8348进行了热疗结合化疗实验,以癌细胞存活率(台盼蓝排斥试验)和癌细胞形态变化评价实验结果。在37℃—43℃范围内,随着温度上升,顺铂(DDP)和羟基喜树碱(OPT)杀癌协同效应增加,癌细胞变性坏死增多,存活率明显下降。
Chemo-thermotherapy of human rectal adenocarcinoma cell line was performed in vitro. The results were evaluated with cellular survival rate ( trypan blue staining) and morphologic change of the adenocarcinoma cell. In a temperature range of 37-43℃ , the synergistic action of the high temperature and the drug DDP or OPT was enhanced as the temperature rose. With the same dose of drug and same length of time of heating, the cellular survival rate obviously declined and the tumor cells showed more serious degeneration and necrosis as the temperature rose further.
出处
《第一军医大学学报》
CSCD
1992年第1期37-39,共3页
Journal of First Military Medical University
基金
中国人民解放军医药卫生"七五"攻关课题
关键词
直肠腺肿瘤
癌
热疗
human rectal adenocarcinoma
HR-8348 cell line
chemo-thermoth-erapy
