摘要
用放射免疫法测定了常年性变应性鼻炎(PAR)、非变应性鼻炎(NAR)患者及健康对照者(NC)血浆及鼻分泌物中的环核苷酸含量。结果表明,PAR组血浆及鼻分泌物中的cAMP均较NAR组(P<0.05)及NC组(P<0.01)为低,cAMP/cGMP比值亦较NC组(P<0.01)为低。
The levels of cAMP and cGMP in both plasma ( BP ) and nasal secretion ( NS) were determined with competitive RIA in 129 subjects including 65 patients with perennial allergic rhinitis(PAR) ,27 patients with nonallergic rhinitis ( NAR)and 37 normal control ( NC). The cAMP levels and cAMP/cGMP ratio of either BP(8.83± 0.84pmol/ml, 2.46±0.82) or NS (8.90±0.76 pmol/ml, 2.50±0.30)in the PAR group were significantly reduced (P<0.0l)as compared with those of the NC group where those values were shown to be 18. 36 ± 1. 60pmol/ml, 3.73±0.69; 15.14 ± 1.52 poml/ml, and 4.58 ± 0.75, respectively. We conclude that cyclic nucleotides play an important role in the pathogenesis of PAR.
出处
《第一军医大学学报》
CSCD
1992年第1期34-36,共3页
Journal of First Military Medical University
关键词
鼻炎
常年性
变应性
环核苷酸
rhinitis, perennial, allergic
cyclic nucleotide
