摘要
作者采用放射免疫方法测定28例肺心病急性加重期患者血清β_2-微球蛋白(β_2-MG)、Tamm-Horsfall蛋白(THP)及24 h尿β_2-MG、THP和白蛋白(Alb)水平,结果表明,肺心病组血清和尿THP含量显著降低(P<0.05),血清、尿β_2-MG及尿Alb浓度显著升高(P<0.01),后三者阳性率显著高于血清中尿素氮及肌酐的阳性率,提示肺心病加重期患者的肾小球及肾小管功能均有不同程度损害.动态观察血清、尿β_2-MG和THP,及尿Alb变化,是判断其早期肾功能损害的敏感方法.
By radioimmunoassay, β2-microglobulin (β2-MG) and Tamm-Horsfall protein (THP)in serum, and β2 -MG.THP and albumin (Alb) in urine for 24 h were measured in 28 patients with cor pulmonale during acute aggravating phase. It indicated that level of βb2-MG in serum and urine and Alb in urine in the patients had an obvious increase (P<0.01), however, THP in serum and urine decreased significantly (P<0.05). The positive rate of those indexes used is notably superior to urea nitride and creatinine in serum. It showed that there were various degrees of functional damages in renal glomeruli and tubules in those patients. And it was a very sensitive index to determine some damages in renal function by observing β2-MG, THP in serum and urine and Alb in urine.
出处
《第四军医大学学报》
1992年第5期381-383,共3页
Journal of the Fourth Military Medical University
关键词
肾功能试验
蛋白
肺心病
清蛋白
pulmonary heart disease
kidney function tests
protein
