摘要
作者通过复制甘油致兔急性肾功能衰竭的动物模型,分组观察了中药茅丹黄及西药硝苯啶、潘生丁结合治疗兔肾衰的疗效及茅丹黄的预防作用.45只兔随机分为:肾衰对照(C_0)、西药治疗(T_0)、大剂量茅丹黄及T_0结合治疗(T_1)、小剂量茅丹黄及T_0结合治疗(T_2)、大剂量茅丹黄预防后T_1治疗(PT).实验前动物所取数据为正常对照(C_N).结果发现肾血流量(ml/min):C_N为25.88±8.71.第1日:C_0 9.70±1.8L;T_0 13.01±2.32;T_1 14.76±5.14;T_2 15.75±4.51;PT 19.24±4.77.第5日:C_0 10.27±2.70;T_0 14.48±2.99;T_1 17.92±5.28;T_215.96±5.26;PT 23.03±4.29.肾功能(BUN,sCr)同肾血流量大小、肾组织学改变呈平行关系.
The animal model of glycerol-induced acute renal failure (ARF) with rabbits was used to study the protective effects of the integrated maodanhuang, nifedipini and dipyridamoli. Fourty-five rabbits were divided into 5 groups randomly, i.e. ARF (C0), preventing (PT), nifedipini and dipyridamoli (T0), the large amount maodanhuang and T0 (T1), the small amount maodanhuang and T0 (T2). The data observed before the experiment were normal control (CN). The renal hemodynamics, renal function (BUN, sCr ) and renal morphology were observed. The results on the first day showed as follows: renal flow (ml/min): C0 9.70±1.81; T0 13.01 ±232; T1 1476± 5.14; T2 15.75±451; PT 19.24±4.77. On the fifth day, renal flow (ml/min): C0 10.27±2.70; T0 14.48±2.99; T1 17.92±5.28; T2 15.96±5.26; PT 23.03±4.29. Normal control (CN): 25.88 ± 8.71. The relationships were parallel. We also analysed the mechanism of glycerol-induced ARF and the protective function of maodanhuang.
出处
《第四军医大学学报》
1992年第5期373-376,共4页
Journal of the Fourth Military Medical University
关键词
茅丹黄
硝苯啶
潘生丁
肾衰竭
renal failure, acute
renal hemodynamics
renal function
maodanhuang
nifedipini
dipyridamoli
