摘要
本文观察慢性缺氧兔和停止缺氧后心功能、双心室重量指数及双侧心室β-肾上腺素能受体的动态变化及心肌和外周血淋巴球变化之间关系。结果表明:(1)慢性缺氧引起右室收缩压、右室dp/dt max及右室重量指数增加,返回平原后25d除右室重量外,余上述指标恢复正常。(2)缺氧第7、15和30天右室和左室β-受体数目减少,停止缺氧25d后左室受体数目恢复正常,但右室β-受体数仍低。(3)心室与淋巴球β-受体变化呈正相关。以上结果提示缺氧性右心室肥大伴有β-受体数减少,而外周血淋巴球β-受体密度可反映心肌受体变化。
The dynamic changes of the functions and the weight index of the 2 ventricles and the density of β-adrenoceptors in the myocardium were observed and the correlation between the changes of β-adrenoceptors of the myocardium and.the peripheral lymphocytes was investigated during and after intermittent chronic hypbxia in rabbits.The fingings were as follows.(1)Chronic hypoxia resulted in an increase of systolic pressure,dp/dtmas and weight index of the right ventricle.25 days after the restoration of normal oxygen supply,systolic pressure and dp/dtomas of the right ventricle became normal but its weight index remained increased.(2)The density of β-adrenoceptors of the 2 ventricles was reduced on the 7th,15th and 30th day of hypoxia as compared with that of the control.25 days after the restoration of oxygen supply,the density of β-adrenoceptors became normal in the left ventricle but remained decreased in the right ventricle.(3)There was a positive correlation between the changes of β-adrenoceptors in the 2 ventricles and peripheral lymphocytes.The findings suggest that hypoxia-induced hypertrophy of the right ventricle is usually accompanied with a decreased density of its β-adrenoceptors and thedensity of β-adrenoceptors of peripheral lymphocytes can reflect the changes of β-adrenoceptors in the myocardium.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1992年第3期230-234,共5页
Journal of Third Military Medical University
关键词
血缺氧
心肌
受体
肾上腺素能
anoxemia
myocardium
receptors
adrenergic
beta
lymphocytes
