摘要
循环内皮细胞(CEC)检测能在活体内研究血管内皮细胞(VEC)的变化,具有较高的临床应用价值,但其来源尚待研究,尤其缺乏从VEC过渡到CEC的直接证据。本文采用人脐静脉内皮细胞培养等手段,对CEC的来源进行了比较细致的研究。结果表明:(1)存在于正常人外周血中的CEC来源于正常代谢过程中脱落的VEC;(2)本文获得了从VEC过渡到CEC的直接证据;(3)CEC的形成是一渐变过程。
Obsevation on the circulating endothelial cells (CEC) can be used to study the changes of the vascular endothelial cells (VEC) in vivo,which is quite valuable in its clinical application.Neverthiless.the origin of CEC remains not clarified.In this study,the origin of CEC was investigated with cultures of the endothelial cells of human umbilical vein.It was found that CEC is a kind of cells existing in circulating blood and originating from desquamated VEC under physiological conditions.The direct proof of this conversion was provided.And the conversion of VEC to CEC is a process of steady progression.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1992年第3期251-254,共4页
Journal of Third Military Medical University
基金
国家自然科学基金
关键词
内皮
细胞
培养的
脐静脉
endothelium
cells
cultured
umbilical veins
