摘要
本研究采用猪腹部高速钢珠致伤模型,观察心脏的形态功能变化。结果表明,伤后即刻活杀组动物(n=5)全部出现左心室内膜片状出血,光电镜检查可见心内膜下和心肌纤维间灶性出血,心肌细胞水肿,线粒体肿胀变性。伤后观察组(n=7)在伤后常规补液,左心功能显著减弱,血清磷酸肌酸激酶同功酶MB(CK-MB)含量显著升高。伤后72h活杀病检结果与伤后即刻活杀组相似。对照组(n=3)采用大量放血活杀致死,心脏病检无明显的形态学变化。
The morphological and pathophysiological manifestations of theheart after abdominal gun-shot wound created by a model-53 smooth bore gun of 6.35 mm in caliber with 1.03 g steel ball were observed in 15 pigs,which were randomized into 3 groups.Five animals of the first group were killed immediately after wounding and all the animals showed small spotty flat hemorrhages on the endocardium of the left ventricle under gross inspection.Focal or small flat hemorrhages on the myocardium and under the endocardium were found under optical microscopy.Under electron microscopy,myofibrilla gaps were widened and filled with fluid,and mitochondrial swelling or vacuolar degeneration in the myocardium could be seen.7 animals of the second group were infused and monitored until they were killed 72 hours after wounding.It was found that there were varying degrees of functional disorder of the left ventricle in every animal.The serum level of creatine kinase isozyme MB increased significantly.The 3 pigs of the third group were killed with large andrapid blood-shedding without gun-shot wound and showed no similar pathological changes.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1992年第2期128-131,共4页
Journal of Third Military Medical University
关键词
创伤
枪弹
心脏损伤
腹部
wounds, gunshot
heart injuries
phosphorylase kinase
phos-phocreatine
swine
