摘要
本实验采用大鼠离体右心房、右心室肌条模型,研究了对离体心肌有负性变力作用浓度的加压素(0.8ng/ml)对右心房、右心室肌条cAMP和cGMP含量的影响。实验结果表明:加压素对心肌的cAMP和cGMP含量均有增加作用,但cGMP含量增加得更为显著,cGMP/cAMP比值由对照组的0.24(心房肌)和0.29(心室肌)分别上升为0.45和0.41。提示加压素的负性变力作用可能与cGMP含最增加有关。
The effect of arginine vasopressin (AW) on the contents of cAMP and cGMP in the isolated right atria and ventricular muscle strips was observed at the concentration possessing negative inotropic effect on the cardiac muscle (0.8ng/ml). Results showed that although there were accumulation of both cAMP and cGMP stimulated by AVP in the cardiac muscle, the increase of cGMP was more pronounced with the rise of cGMP/cAMP ratio from the control value 024 (atria) and 0.29(ventricle) to 0.45 and 0.41 respectively after treatment with AVP. Coupled with the known effect of cGMP in mediating the negative inotropic effect in the heart, cGMP is also a possible mediator of the negative inotropic effect of AVP in the heart. The significance of increase in cAMP stimulated by AVP awaits further studies.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1992年第6期524-526,共3页
Academic Journal of Second Military Medical University
关键词
加压素
心脏
磷酸腺苷
磷酸鸟苷
vasopressin
cardiac muscle
negative inotropic effect
cAMP
cGMP
