摘要
采用放射免疫测定法观察了颅脑伤大鼠脑区、垂体和血浆内神经降压肽免疫活性物质(ir-NT)含量的变化。结果显示,NT含量在下丘脑、垂体、血浆、挫伤处皮层、海马、中央灰质和脊髓在大鼠伤后不同时程有显著改变。脑区、垂体和血浆中NT含量普遍呈显著性降低,而下丘脑、中央灰质和海马在伤后不同时程呈双相改变。额叶皮层和桥延脑在急性颅脑伤状态下NT含量也显示不同程度的改变。这些结果提示,NT可能在颅脑伤病理生理过程中起一定的作用。
The changes of immunoreactive neurotensin (ir-NT) contents in the brain areas, pituitary gland and plasma in the trautized rats were observed by radioimmunoassay. The results showed the significant changes of the ir-NT contents in the hypothalamus, pituitary gland, plasma, injured tissue, hippocampus, central gray and spinal cord in the posttraumatic rats at different intervals. A predominant characterization of the change of ir-NT levels in the brain areas, pituitary gland and plasma, was the dramatical decrease at various times except for the hypothalamus, central gray, and hippocampus with biphasic alterations. The ir-NT contents in the frontal cortex, pons and medulla also displayed changes to different extent under the acute craniocerebral trauma condition These results suggest that NT may play a role in the pathophysiology of traumatic injury.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1992年第4期307-311,共5页
Academic Journal of Second Military Medical University
关键词
神经降压肽
免疫测定法
颅脑损伤
neurotensin
radioimmunoassay
acute brain injury
animals
rat
