摘要
作者研究了急性心力衰竭、慢性心力衰竭、持续性房颤各30例,阵发性房颤和室上性心动过速27例的血浆心房利钠多肽(ANP)、cGMP、肾素活性(PRA)、血管紧张素Ⅱ(ATⅡ)和精氨酸加压素(AVP)水平,发现4组患者血浆ANP和cGMP均明显升高,两者的相关系数分别为0.840、0.775、0.670和0.842(P<0.01)。前3组血浆PRA、ATⅡ和AVP水平高于第4组,24h尿量和尿钠减少,而第4组有多尿。结果提示,4组患者血浆ANP的生物学活性基本相同,急慢性心力衰竭和慢性房颤患者不出现利尿反应可能与肾素-血管紧张素和AVP系统过度激活以及肾脏对持续高浓度ANP刺激的耐受有关。
Plasma levels of artial natriuretic polypeptide (ANP), cyclic GMP (cGMP), renin activity (PRA), angiotensin II (AT II) and arginine vasopressin (AVP) were measured by radioimmunoassay in 30 patients with acute heart failure (AHF), 30 chronic heart failure (CHF), 30 chronic atrial fibrillation (CAF) and 27 paraxysmal atrial fibrillation and supraventricular tachycardia (SVT). The results showed that plasma ANP and cGMP levels in all these four groups were significantly higher than those in the normal group (P<0.01). There were significant correlations between plasma ANP and cGMP in every patient group (r=0.840, 0.775, 0.670 and 0.842, respectively, P<0.01). The PRA, AT II and AVP concentrations in patients with AHF, CHF and CAF were significantly higher than those in SVT group. Decreased urine and natrium excretion per 24 hours in AHF, CHF and CAF groups and polyuria in the SVT group were also observed We conclude that plasma ANP in all four patient groups had nearly the same biological activity. The absence of natriuresis in patients with AHF and CHF may be due in part to the over activation of reran-angiotensin system and AW system. Renal resistence to persistent elevated endogenous ANP may also contribute to the sodium retension observed in patients with AHF, CHF and CAF.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1992年第4期322-326,共5页
Academic Journal of Second Military Medical University
基金
青年科技基金
关键词
心力衰竭
钠利多肽
心房
heart failure, congestive
auricular fibrillation
tachycardia, paraxysmal
atrial natriuretic polypeptides
nucleotides, cyclic
patients
