摘要
本文报道微电泳不同递质阻断剂对下丘脑室旁核(PVN)痛单位诱发反应的效应。结果表明:(1)PVN痛单位中,阿托品可阻断38个中的7个;六烃季胺阻断27个中的5个,普奈洛尔阻断25个中的4个;酚妥拉明阻断31个中的6个;赛庚啶对52个中的17个有影响,其中14个压抑诱发反应,3个加强其诱发反应。(2)两种受体阻断剂可阻断同一PVN痛单位的诱发反应;阿托品和赛庚啶阻断27个中的2个;六烃季胺和赛庚啶阻断20个中的3个;普奈洛尔和赛庚啶阻断25个中的2个。结果表明:(1)躯体痛信息到下丘脑PVN传入的递质受体机制的多样性。(2)同一PVN痛单位可能接受不同递质系统的传入。
Effects of microiontophoretically applied transmitter receptor antagonists on the evoked response of “pain” units of PVN in rats by sciatic stimulation were observed. The results showed: (l)The evoked response of 7 out of 38 PVN “pain” units could be blocked by atropine (7/38); 5 out of 27 by hexamethonium; 6 out of 31 by phentolamine (6/31); and 4 out of 25 by propranolol (4/25). Seventeen out of 52 were blocked by cyproheptadine (17/52), but 3 out of 52 were augmented by cyproheptadine (3/52). (2) The evoked response of the same “pain” unit could be blocked by two antagonists: the evoked response of 2 out of 27 PVN “pain” units could be blocked by atropine and cyprohepadine; 3 out of 20 by hexamethonium and cyproheptadine; 2 out of 25 by prepamolol and cyproheptadine. These results suggest that the noxious somatic input to PVN involves 5-HT, cholinergic and adrenergic transmitter receptor mechanisms and that the convergence of various transmitter systems on PVN “pain” unit is indicated.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1992年第2期137-141,共5页
Academic Journal of Second Military Medical University
关键词
微电泳
阻断剂
坐骨神经
大鼠
PVN
hypothalamus
paraventricular nucleus
unit discharges
microiontophoresis
transmitter receptor antagonist
sciatic nerve
rats
