摘要
目的 :观察尼莫地平对重型颅脑损伤患者血液流变学及机体抗氧化能力的影响并探讨其临床意义。方法 :6 8例重型颅脑损伤患者分为尼莫地平组 38例和对照组 30例 ,2组治疗前及治疗 1个月后检测血液流变学及超氧化物歧化酶 (SOD)、丙二醛 (MDA)水平。结果 :2组患者治疗前血液粘度增高 ,血清SOD活力降低且MDA含量增高 (P <0 .0 5 )。治疗后尼莫地平组全血粘度高低切变值和血浆粘度明显改善 (P <0 .0 5 ) ,血清SOD活力增高 (P <0 .0 5 ) ,MDA含量显著降低 (P <0 .0 5 ) ,与对照组比较差异有显著性 (P <0 .0 5 )。结论 :在常规治疗和康复训练的基础上加用尼莫地平治疗可明显改善重型颅脑损伤患者血液流变学情况 ,提高机体抗氧化能力 ,减轻自由基的损害。
Objective: To observe the effect of Nimodipine on the hemorrheology and anti-oxidizing power in severe traumatic brain injury and exlpore the clinical significance. Methods: 68 cases of severe traumatic brain injury were divided into Nimodipine-treated group ( n =38) and control group ( n =30). The hemorrheology and the level of serum superoxide dismutase (SOD) and malondialdehyde (MDA) were measured before and one month after treatment. Results: The viscosity of the patients in the two groups before treatment was increased, and the levels of SOD was decreased and MDA increased ( P <0.05). As compared with the control group, the whole blood viscosity shear value and plasma viscosity were improved significantly in the Nimodipine-treated group and the level of SOD was increased and MDA was decreased obviously ( P < 0.05 ). Conclusion: Nimodipine can improve th hemorrheology of the patients with severe traumatic brain injury and increase the anti-oxidizing power to alleviate the damage by oxygen free radicals.
出处
《中国康复》
2002年第4期207-208,210,共3页
Chinese Journal of Rehabilitation
关键词
尼莫地平
颅脑损伤
血液流变学
氧自由基
Nimodipine
traumatic brain injury
hemorrheology, oxygen free radicals
