腺病毒载体介导的野生型P_(53)基因对前列腺癌细胞生长和致瘤能力的抑制效果
Inhibition effect of mucous virus vector induced wild type p53 gene on the growth of prostatic cancer cell
摘要
目的 为探讨用腺病毒载体携带野生型P53基因作为前列腺癌基因治疗的可能性。方法 应用重组人携带野生型P53基因病毒 (Ad WTP53)感染培养的前列腺癌细胞 ,观察表达P53基因蛋白的癌细胞与对照组癌细胞的体外生长和裸鼠体内致瘤能力变化 ,对荷瘤裸鼠瘤体周围注射Ad WTP53,观察治疗组和对照组肿瘤生长的变化。结果 感染Ad WTP53的前列腺细胞体外生长和裸鼠体内致瘤能力明显下降 ,荷瘤裸鼠瘤体周围注射Ad WTP53后肿瘤生长速度明显减慢。结论 证实了野生型P53基因是一种抑癌基因 。
出处
《辽宁医学杂志》
2002年第5期241-242,共2页
Medical Journal of Liaoning
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