摘要
目的 研究慢性肺心病急性发作期患者谷丙转氨酶 (ALT)、谷草转氨酶 (AST)、乳酸脱氢酶(LDH)、羟基丁酸脱氢酶 (HBDH)、磷酸肌激酶 (CPK)的变化。方法 采用酶催化L 丙氨酸与α 酮戊二酸法测定ALT ;采用酶催化天冬氨酶与α 酮戊二酸法测定AST ;采用酶催化α 丁酸与NADH的反应法测定HBDH ;采用酶催化磷酸肌酸与ADP反应法测定CPK ;采用Bayer 5 5 0血气分析仪测定动脉血氧分压。结果 肺心病急性期患者血氧分压显著低于肺心病缓解期患者 (P =0 .0 0 0 1)。肺心病急性期患者血清ALT、AST、LDH、HBDH均显著高于肺心病缓解期患者 (P =0 .0 2 6,P =0 .0 40 ,P =0 .0 0 3 ,P =0 .0 0 0 1) ,而CPK差异无显著性 (P =0 .10 7)。结论 肺心病的急性发作可能造成机体ALT、AST、LDH、HBDH的升高。
Objective To study the changes of serum enzymes of cor pulmonale patients in acute outbreak period.Methods The method of enzyme catalytic reaction of L alanine and α ketoglutaric acid was used to determine the level of ALT in serum,at the same time,the method of enzyme catalytic reaction of aspartic acid and α ketoglutaric acid was used to test the level of AST in serum.Serum CPK was determined by the method of catalytic reaction of phosphocreatine and ADP.Bayer 550 air blood instrument was used to determine the partial pressure of oxygen in blood.Results Oxygen pressure of the acute outbreak group was significantly lower than that of the alleviate group.The ALT,AST,LDH and HBDH levels of serum in the acute outbreak preiod of cor pulmonale group were higher than those of the remission group.(P=0.026,P=0.040,P=0.003,P=0.001,P=0.0001),but there was no difference in serum CPK between the two groups(P=0.107).Conclusion The outbreak of chronic cor pulmonale can increase the level of ALT,AST,LDH and HBDH in serum,and the low oxygen pressure maybe the cause of the increase.
出处
《河北医药》
CAS
2002年第12期936-937,共2页
Hebei Medical Journal
