摘要
目的 探讨抑癌其因p1 6及肿瘤抑制基因nm2 3-H1 在膀胱中的表达及临床意义。方法 应用免疫组织化学s p法检测 1 8例正常膀胱组织中及 38例膀胱移行细胞癌组织中p1 6及nm2 3-H1 的表达。结果 p1 6在正常组织、膀胱癌中阳性表达率分别为 88 8% ( 1 6/1 8)、47 4% ( 1 8/38) ,两者间有显著差异性 (P <0 0 1 )。nm2 3-H1 在正常膀胱组织、膀胱癌中阳性表达率分别为 83 3% ( 1 5 /1 8) ,44 7% ( 1 7/38)。两者间有显著差异 (P <0 0 1 )。提示 ,p1 6、nm2 3-H1 阳性表达率与膀胱移行细胞癌的临床分期、临床分级、肿瘤大小及是否转移有密切关系。结论 p1 6、nm2 3-H1 在膀胱癌中的阳性表达对抑制肿瘤生长 ,浸润和转移起重要作用 。
Objective To study the expression and implication of p16 and nm23-H 1 in human bladder carcinoma.Methods Immunohistochemistry method was used to detect p16 and nm23-H 1 expression in 18 noncancerous normal bladder tissues and 38 primary bladder carcinoma.Results The positive expression rete of p16 in normal bladder tissues,primary bladder carcinoma tissres was 88 8%?47 4%,respectively with significant difference( P <0 01).The positive expression rate of nm23-H 1 in normal bladder tissues and primary bladder carcinoma tissues was 83 5%?44 7%,respectively with significant difference( P <0 01).The positive espression rate of p16 and nm23-H 1 were closely correlately with clincopathological stages?pathlolgyical grades?tunor size and metastasis.Conclusions Expression of p16 and nm23-H 1 in bladder carcinoma play an important role in suppression of invasive growth and metastasis of tumor,might be a good indicator of predicting metastasis and porgnosis and evaluation the biological behavior of bladder carcinoma.
出处
《兰州医学院学报》
2002年第4期29-31,共3页
Journal of Lanzhou Medical College
