摘要
As the main component of lipids,fatty acids are essential in supporting life activities regarding energy supply,cell composition,and signaling molecules.Enhancement of fatty acid(FA)synthesis,storage,and catabolism is observed in various cancer cells.In addition,it has become clear that tumor cells exhibit plasticity in fatty acid metabolism to facilitate aggression and treatment resistance.Here,we describe cellular fatty acid metabolism changes associated with tumor development and therapeutic resistance.Potential inhibitors of fatty acid metabolism are also discussed for tumor therapy.Therefore,exploring the targets of FA metabolism in cancer to improve the efficiency of cancer therapy is of great interest.
基金
supported by The National Key Research and Development Program of China(2020YFA0112300)
National Natural Science Foundation of China(82373089,81930075,81772799)
Program for Outstanding Medical Academic Leader in Shanghai(2019LJ04)
Program of Shanghai Academic/Technology Research Leader(20XD1400700).
