摘要
目的分析血清沉默信息调节因子1(SIRT-1)、氨基末端脑钠肽前体(NT-proBNP)、血栓素B2(TXB2)水平与急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入治疗(PCI)术后衰弱发生风险的关系。方法回顾性纳入并观察2022年12月至2024年12月期间在邢台市中心医院就诊的200例STEMI并行PCI术患者。统计STEMI患者PCI术后衰弱发生情况及一般资料;采用多因素Logistic回归分析探讨PCI术后衰弱发生的影响因素;采用受试者操作特征(ROC)曲线分析血清SIRT-1、NT-proBNP、TXB2水平评估STEMI患者PCI术后衰弱的价值。结果200例STEMI患者PCI术后,78例发生衰弱,其发生率为39.00%(78/200),并将其归为衰弱组,122例未发生衰弱,将其归为非衰弱组。单因素分析结果显示,相较于非衰弱组,衰弱组的年龄、营养不良患者构成比及SIRT-1、NT-proBNP、TXB2水平均更高,差异均有统计学意义(P<0.05)。多因素Logistic回归分析证实,年龄、营养不良及SIRT-1、NT-proBNP、TXB2水平升高均为STEMI患者PCI术后衰弱发生的独立危险因素(P<0.05)。通过ROC分析验证,上述血清指标均可用于STEMI患者PCI术后衰弱的评估,曲线下面积分别为0.705、0.760、0.763,均有P<0.05。结论年龄、营养不良及血清SIRT-1、NT-proBNP、TXB2水平均是STEMI患者PCI术后衰弱的影响因素,且血清SIRT-1、NT-proBNP、TXB2水平均可用于PCI术后衰弱情况的评估,临床应引起足够重视。
Objective To analyze the relationship between the levels of serum silent infor-mation regulator 1(SIRT-1),N-terminal pro-brain natriuretic peptide(NT-proBNP),and thromboxane B2(TXB2)and the risk of frailty in patients with acute ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods A total of 200 patients with STEMI who underwent PCI in Xingtai Central Hospital from December 2022 to December 2024 were retrospectively included and observed.The occurrence of frailty after PCI and general data in STEMI patients were statistically analyzed.The influencing factors of frailty after PCI were analyzed by multivariate Logistic regression analysis.The value of serum SIRT-1,NT-proBNP and TXB2 levels in evaluating frailty after PCI in STEMI patients was analyzed by receiver operator characteristic(ROC)curve.Results Among 200 STEMI patients after PCI,78 cases developed frailty,with an incidence rate of 39.00%(78/200),and they were classified as the frailty group.One hundred and twenty-two cases did not develop frailty and were classified as the non-frailty group.The results of univariate analysis showed that compared with the non-frailty group,the age,the proportion of malnutrition patients,the levels of SIRT-1,NT-proBNP and TXB2 in the frailty group were higher,and the differences were statistically significant(P<0.05).Multivariate Logistic repression analysis confirmed that age,malnutrition,elevated SIRT-1,NT-proBNP and TXB2 levels were all independent risk factors for frailty after PCI in STEMI patients(P<0.05).ROC analysis verified that all the above indicators could be used to evaluate frailty after PCI in STEMI patients.The areas under the curve were 0.705,0.760,and 0.763,all with P<0.05.Conclusion Age,malnutrition,serum levels of SIRT-1,NT-proBNP and TXB2 are all influencing factors of frailty after PCI in STEMI patients.Moreover,the levels of serum SIRT-1,NT-proBNP and TXB2 can all be used to evaluate frailty after PCI,which should be given sufficient attention in clinical practice.
作者
吴玉静
范俊利
李欣
谷艳侠
WU Yujing;FAN Junli;LI Xin(Cardiac Care Unit,Xingtai City Central Hospital,Xingtai Hebei 054000,China)
出处
《临床和实验医学杂志》
2026年第5期464-468,共5页
Journal of Clinical and Experimental Medicine
基金
邢台市科技局自筹项目(编号:2024ZC193)。
关键词
心肌梗死
年龄因素
营养不良
经皮冠状动脉介入
衰弱
沉默信息调节因子1
氨基末端脑钠肽前体
血栓素B2
Myocardial infarction
Age factors
Malnutrition
Percutaneous coronary intervention
Frailty
Silent information regulator 1
N-terminal pro-brain natriuretic peptide
Thromboxane B2
