摘要
目的观察支气管镜冷冻联合局部抗结核药物灌注治疗支气管结核的效果。方法选择郑州市第六人民医院2021年6月—2024年6月间收治的支气管结核患者124例,采用随机数字表法分组,对照组62例,观察组62例。所有患者按照要求接受抗结核治疗与支气管镜下局部灌注异烟肼,观察组联合支气管镜冷冻治疗。比较两组患者的痰菌转阴率,抗结核疗程结束的治疗效果、血清指标[红细胞沉降率(erythrocyte sedimentation rate,ESR)、白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)]及不良反应发生率。结果较对照组,观察组患者治疗各时点痰菌转阴率均高,抗结核治疗疗程结束的治疗总有效率高(P<0.05)。两组患者治疗3个月时,血清ESR、IL-6、CRP水平均降低,且观察组更低(P<0.05)。对照组发生2例咯血、3例气道痉挛、2例发热,不良反应发生率为11.29%(7/62);观察组发生1例咯血、3例气道痉挛、2例发热,发生率为9.68%(6/62),两组组间差异无统计学意义(P>0.05)。结论支气管镜冷冻联合局部药物灌注治疗能提高支气管结核患者痰菌转阴率,增强整体的治疗效果,且不增加不良反应,治疗方案相对安全。
Objective To observe the effect of bronchoscopy freezing combined with local anti tuberculosis drug infusion in the treatment of bronchial tuberculosis.Methods Totally 124 patients with bronchial tuberculosis admitted to the hospital between January 2023 and June 2024 were included.They were randomly divided into a control group and an observation group,with 62 patients in each group,using a random number table method.All patients received anti tuberculosis treatment as required,and on this basis,local infusion of isoniazid was administered under bronchoscopy.The observation group received combined bronchoscopy cryotherapy.The sputum bacteria negative conversion rate,the therapeutic effect at the end of the anti tuberculosis treatment course,serum indicators[Erythrocyte sedimentation rate(ESR),interleukin-6(IL-6),C-reactive protein(CRP)]and the incidence of adverse reactions were compared between the two groups of patients.Results The sputum conversion rate of the observation group patients at all treatment points was higher than that of the control group,and the total effective rate of anti tuberculosis treatment at the end of the course was higher than that of the control group(P<O.05).After one month of treatment,the serum levels of ESR,IL-6,and CRP in both groups of patients decreased,and the observation group was lower than the control group(P>0.05).The control group experienced 2 cases of hemoptysis,3 cases of airway spasm,and 2 cases of fever,with an adverse reaction rate of 11.29%(7/62).The observation group experienced 1 case of hemoptysis,3 cases of airway spasm,and 2 cases of fever,with an incidence rate of 9.68%(6/62).There was no statistical significant difference be tween the two groups(P>0.05).Conclusion Bronchoscopy cryotherapy combined with local drug infusion can improve the sputum conversion rate of patients with bronchial tuberculosis,enhance the overall treatment effect,and do not increase adverse reactions.The treatment regimen is relatively safe.
作者
孙紫琳
武艳霞
SUN Zi-lin;WU Yan-xia(Tuberculosis Department,Sixth People's Hospital of Zhengzhou City,Zhengzhou,Henan 450000,China)
出处
《医药论坛杂志》
2026年第6期626-630,共5页
Journal of Medical Forum
基金
2022年度河南省传染病医院院级项目(202208)。
关键词
支气管结核
冷冻治疗
支气管镜
药物灌注
炎症
转阴率
安全性
Bronchial tuberculosis
Cryotherapy
Bronchoscopy
Drug infusion
Inflammation
Negative conversion rate
Safety
