摘要
目的 基于“脑肠轴”学说观察小续命汤加味大黄治疗风痰阻络证急性缺血性脑卒中(AIS)的临床疗效及其机制。方法 将我院80例风痰阻络证AIS患者随机分为观察组41例与对照组39例。对照组给予规范西医治疗,观察组在对照组治疗基础上联合使用小续命汤加味大黄。比较两组总有效率,美国国立卫生院卒中量表(NIHSS)、改良Rankin量表(mRS)、日常生活能力评分(ADL)、排便症状评分,肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、胃动素(MTL)、血管活性肠肽(VIP)水平。结果 治疗后,观察组总有效率高于对照组(P<0.05);两组NIHSS、mRS、排便症状评分低于治疗前,ADL评分高于治疗前,观察组上述指标的改善程度均优于对照组(P<0.05);两组TNF-α、IL-6、VIP水平低于治疗前,MTL水平高于治疗前,观察组上述指标的改善程度均优于对照组(P<0.05)。结论 在西医常规治疗基础上联合小续命汤加味大黄可有效缓解风痰阻络证AIS患者的神经功能损伤,同时改善胃肠功能及炎症反应状态,其机制可能是通过脑肠轴途径发挥协同治疗作用,具有较高的临床推广价值。
Objective To observe the clinical efficacy and mechanism of Xiaoxuming Decoction plus Rhubarb in treatment of acute ischemic stroke(AIS)with wind-phlegm obstruction syndrome based on the"brain-gut axis"theory.Methods Eighty AIS patients with wind-phlegm obstruction syndrome were randomly divided into observation group(41 cases)and control group(39 cases).Control group received standard Western medical treatment,while observation group received Xiaoxuming Decoction plus Rhubarb on the basis of control group.The total effective rate,National Institutes of Health Stroke Scale(NIHSS),modified Rankin Scale(mRS),and Activities of Daily Living(ADL)scores,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),motilin(MTL),and vasoactive intestinal peptide(VIP)levels were compared between the two groups.Results After treatment,the total effective rate in observation group was significantly higher than that in control group(P<0.05);compared with before treatment,NIHSS,mRS,and defecation symptom scores in both groups were lower,while ADL scores were higher,and the above indicators were superior in observation group to those in control group(P<0.05);TNF-α,IL-6,and VIP levels in both groups were lower,while MTL levels were higher,and the above indicators were superior in observation group to those in control group(P<0.05).Conclusion On the basis of routine Western medical treatment,combining Xiaoxuming Decoction with added Rhubarb can effectively alleviate neurological damage in AIS patients with wind-phlegm obstruction syndrome while improving gastrointestinal function and inflammatory status.Its mechanism might involve a synergistic therapeutic effect via the brain-gut axis,which has high clinical promotion value.
作者
王爱萍
陈臻
黄志强
王龙海
WANG Ai-ping;CHEN Zhen;HUANG Zhi-qiang;WANG Long-hai(Dazhou Integrated TCM and Western Medicine Hospital,Dazhou 635000)
出处
《湖北中医药大学学报》
2026年第1期101-103,共3页
Journal of Hubei University of Chinese Medicine
基金
四川省中医药管理局科学技术研究专项项目(项目编号:2023MS142)。
关键词
缺血性脑卒中
风痰阻络证
脑肠轴
小续命汤加大黄
Ischemic stroke
Wind-phlegm obstruction syndrome
Brain-gut axis
Xiao Xuming Decoction plus Rhubarb
