摘要
背景:长期慢性高血糖诱导的氧化应激和抗氧化系统受损是构成糖尿病发生与发展的核心机制之一。铁死亡是一种由铁依赖性脂质过氧化驱动的新型程序性细胞死亡形式,因其与糖尿病的关联性,引起广泛学术关注。目的:采用文献计量学方法揭示糖尿病领域中铁死亡相关研究的现状和趋势,旨在提供有助于推动相关领域的学术参考。方法:基于Web of Science核心集数据库,时间跨度设为2015-01-01/2025-01-01,检索应用于糖尿病领域中铁死亡相关的文献797篇。利用知识图谱软件CiteSpace(6.2.R1)对去重后获得的高质量文献758篇进行发文量、国家/研究机构合作、高影响力作者/文献共被引、关键词共现/聚类/突现等主题热点、国际前沿趋势可视化分析及科学图谱的可视化呈现。结果与结论:①文献计量显示糖尿病领域中铁死亡相关研究呈大幅增长态势,纳入758条符合标准的记录系统分析;②其中Linkermann,Andreas为最高产学者,而Dixon SJ以420次被引频次确立学术影响力标杆,期刊《Cell》为关键知识传播枢纽,最常见的关键词包括氧化应激、细胞死亡以及脂质过氧化,其聚类主要集中在糖尿病肾病及心肌病、谷胱甘肽过氧化物酶4、程序性坏死等方面;③铁死亡调控网络的应用探索不断深化,已成为糖尿病及其并发症靶向治疗研究的新兴范式。
ACKGROUND:Oxidative stress induced by chronic hyperglycemia and impaired antioxidant systems are one of the core mechanisms underlying the onset and progression of diabetes mellitus.Ferroptosis,a new type of programmed cell death caused by iron-dependent lipid peroxidation,has received considerable academic interest due to its association with diabetes.OBJECTIVE:To reveal the current status and trends of ferroptosis-related research in the field of diabetes mellitus using bibliometric methods,aiming to offer academic resources to further develop this research area.METHODS:Based on the Web of Science Core Collection database,with a time span set from January 1,2015 to January 1,2025,797 articles related to ferroptosis in the field of diabetes mellitus were retrieved.A visual analysis was conducted on 758 high-quality articles obtained after removing duplicates using the knowledge mapping software CiteSpace(6.2.R1),including publication volume,country/institutional collaboration,co-citations of high-impact authors/articles,keyword co-occurrence/clustering/emergence,international frontier trends,and visualization of scientific networks.RESULTS AND CONCLUSION:(1)Bibliometric analysis indicates a substantial increase in ferroptosis-related research within the field of diabetes mellitus,with 758 records meeting criteria for systematic analysis.(2)Andreas Linkermann was the most prolific author,while Dixon SJ set an academic influence benchmark with 420 citations.The journal Cell demonstrated the highest co-citation frequency.The dominant keywords included oxidative stress,cell death,and lipid peroxidation,with their clusters primarily concentrated in diabetic nephropathy and cardiomyopathy,glutathione peroxidase 4,and programmed necrosis.(3)The investigation into ferroptosis regulatory networks in applications is growing,establishing itself as a novel approach for targeted therapy research in diabetes mellitus and its complications.
作者
陈纤纤
徐成凤
黄文艺
阳宸凡
苏桐珊
李瑜
闫语
李春
Chen Xianxian;Xu Chengfeng;Huang Wenyi;Yang Chenfan;Su Tongshan;Li Yu;Yan Yu;Li Chun(School of Nursing,Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong Province,China;Research Center for Integrated Traditional Chinese and Western Medicine,School of Basic Medical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong Province,China;Academic Affairs Office,Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong Province,China)
出处
《中国组织工程研究》
北大核心
2026年第25期6691-6700,共10页
Chinese Journal of Tissue Engineering Research
基金
广东省高等学校科研平台与项目(2022KTSCX025)
广州中医药大学2025年“固本”工程一级学科能力提升项目(GZY2025GB0907),项目负责人:李春
广州中医药大学2025年“固本”工程一级学科能力提升项目(GZY2025GB0915),项目负责人:闫语
广州市科技计划项目(202201011394)。
