摘要
结直肠癌作为发病率和死亡率在全球范围内排名前列的恶性消化道肿瘤,其每年的新发病例也在不断增加。虽然存在放疗、化疗和手术等常规治疗手段,但缺乏早期诊断、预后差及耐药性等问题也给结直肠癌患者带来巨大的困扰。结直肠癌的发病机制复杂多样,因此寻求安全有效、可靠且多靶点的治疗方案已成为临床的迫切需求。Hippo信号通路与肿瘤发生、癌细胞侵袭和迁移及耐药性等机制密切相关,能广泛参与结直肠癌的发生发展,靶向该通路来防治癌症已成为近年来的重要研究方向。中医药具有多方位、多途径和多靶点的作用优势,通过提高患者免疫功能、改善生活质量和延长生存时间等功能已成为抗结直肠癌的重要治疗手段。研究发现,中药活性成分黄酮类、萜类、酚类、生物碱类、醌类、木脂素类和皂苷类等,及中药复方加味四君子汤、解毒三根汤、健脾解毒方和祛瘀解毒汤对Hippo信号通路具有显著的靶向作用,可通过诱导结直肠癌细胞自噬和凋亡、抑制上皮间质转化、逆转肿瘤耐药性、阻滞癌细胞周期等机制来发挥抗结直肠癌作用。该文就国内外有关中医药调控Hippo信号通路来防治结直肠癌的作用机制研究进行检索总结并作一综述,以期为临床上防治结直肠癌的中医药应用和新药研发提供新的参考和思路。
Colorectal cancer,a leading malignant gastrointestinal tumor globally in terms of incidence and mortality,has seen a consistent annual rise in newly diagnosed cases.While conventional therapies like radiotherapy,chemotherapy,and surgery are available,problems such as lack of early diagnosis,poor prognosis,and drug resistance remain significant burdens for patients.Given the complex and diverse pathogenesis of colorectal cancer,there is an urgent clinical need for safe,effective,reliable,and multi-targeted therapeutic strategies.The Hippo signaling pathway,closely linked to mechanisms like tumorigenesis,cancer cell invasion,migration,and drug resistance,extensively participates in the occurrence and development of colorectal cancer,so targeting the signaling pathway for cancer prevention and treatment has become a crucial research direction in recent years.Traditional Chinese medicine(TCM)offers multi-faceted,multi-pathway,and multi-target advantages and becomes an important therapy for colorectal cancer by enhancing patients'immunity,improving the life quality,and prolonging survival.Studies show that the active components of TCM,including flavonoids,terpenoids,phenols,alkaloids,quinones,lignans,and saponins,as well as TCM compounds such as modified Sijunzi decoction,Jiedu Sangen decoction,Jianpi Jiedu compound,and Quyu Jiedu decoction,exhibit significant targeting effects on the Hippo signaling pathway.These TCMs can exert an anti-colorectal cancer effect through various mechanisms,such as inducing cancer cell autophagy and apoptosis,inhibiting epithelial-mesenchymal transition,reversing drug resistance of the tumor,and blocking the cancer cell cycle.This paper reviewed and analyzed Chinese and international research on the action mechanisms of TCM in regulating the Hippo signaling pathway for the prevention and treatment of colorectal cancer with a comprehensive overview presentation,aiming to provide new references and ideas for the clinical application of TCM and the development of new pharmacological agents in the prevention and treatment of colorectal cancer.
作者
曾朔
胡素芹
胡洋
罗磊
李明彦
张勤生
ZENG Shuo;HU Suqin*;HU Yang;LUO Lei;LI Mingyan;ZHANG Qinsheng(Henan University of Chinese Medicine,Zhengzhou 450046,China;The Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002,China)
出处
《中国实验方剂学杂志》
北大核心
2026年第8期297-305,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(82305074)
国家中医药管理局中国中医药科技发展中心联合研究项目(CXZH202304)
河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才项目(豫卫中医函[2021]08号)
2022年度河南省重点研发与推广专项(科技攻关)支持项目(222102310240)
河南省中医药科学研究专项(2023ZY2074)。
关键词
Hippo信号通路
中医药
结直肠癌
研究进展
Hippo signaling pathway
traditional Chinese medicine
colorectal cancer
research progress
