摘要
目的:设计基于区块链技术的开发利用系统,解决临床研究数据开发利用中存在的数据易泄露、供需双方信任缺失和成果抢注、仿冒难鉴真等问题。方法:采用分层架构,利用区块链相关技术,构建可信、安全、高效的数据开发共享平台,包括医院端临床研究数据管理、临床研究区块链管理、可信数据空间和区块链基础底座4个模块。通过数据信息上链、数据应用上链和数据档案核验等实践流程,确保数据不可篡改、全程可追溯和安全共享。结果:显著提升了临床研究数据开发利用中的数据安全性、完整性、真实性,以及科研成果的可追溯和验证性,数据信息上链确保了透明性和不可篡改性,数据应用上链实现了安全开发与可信共享,数据档案核验保障了数据的完整性和科研成果的真实性、权威性。结论:系统为临床研究数据的开发利用提供了创新解决方案,为其市场化流通和产业化应用提供重要参考。
Objective To design an open application system based on blockchain technology to address issues in the open application of clinical research data,such as vulnerability to data breaches,lack of trust between supply and demand parties,preemptive registration of research outcomes,counterfeiting,and difficulty in authenticity verification.Methods Employing a layered architecture,the system leverages blockchain-related technologies to construct a credible,secure,and efficient data open platform.This platform comprises four modules:hospital-side clinical research data management,clinical research blockchain management,trusted data space,and blockchain infrastructure.Through practical processes including data information chaining,data application chaining,and data archive verification,the system ensures data immutability,full traceability,and secure sharing.Results The system significantly enhances the security,integrity,and authenticity of clinical research data in open applications.It also improves the traceability and verifiability of scientific achievements.Data information chaining ensures transparency and immutability,data application chaining realizes secure open access and trusted sharing,and data archive verification safeguards data integrity,as well as the authenticity and authority of research outcomes.Conclusion The system offers an innovative solution for the open application of clinical research data,providing important references for its market circulation and industrial application.
作者
夏寒
范骏翔
徐博
李晓洁
何萍
XIA Han;FAN Junxiang;XU Bo;LI Xiaojie;HE Ping(Shanghai Hospital Development Center,Shanghai 200041,China;Shanghai General Hospital)
出处
《中国数字医学》
2026年第4期92-97,共6页
China Digital Medicine
基金
上海市卫生健康委员会2025年卫生健康政策研究课题——医疗健康数据共享流通与可信数据空间研究(2025HP37)
上海市医院协会2024年度医院管理课题——基于安全可信云计算环境下的医疗数据应用模式研究(X2024074)
上海申康医院发展中心2024年度管理研究项目——专病数据采集汇聚及融合治理的协作方法与激励模式研究(2024SKMR-08)。
关键词
临床研究
区块链
数据开发
Clinical research
Blockchain
Data openness
