摘要
目的评估大承气汤对具有内镜逆行胰胆管造影(ERCP)术后胰腺炎(PEP)高危因素患者发生PEP的预防价值。方法回顾性纳入2021年12月至2023年6月在我院接受ERCP治疗且具有PEP高危因素的患者。根据患者ERCP术后是否服用大承气汤分为大承气汤组和对照组。记录并评估患者的一般临床资料、内镜数据及PEP发生情况。结果共纳入60例具有PEP高危因素的患者,其中大承气汤组34例、对照组26例,两组基线数据具有可比性。共11例(18.33%)患者发生PEP,其中大承气汤组6例(17.65%),对照组5例(19.23%),两组PEP发生率差异无统计学意义(P>0.05)。对照组4例(15.38%)发生重症急性胰腺炎(SAP),大承气汤组无SAP发生,大承气汤组SAP发生率低于对照组(P<0.05)。大承气汤组住院时间为(2.59±0.18)d,对照组为(3.27±0.25)d,大承气汤组住院时间短于对照组(P<0.05)。结论对具有PEP高危因素的患者,ERCP术后应用大承气汤可降低重症PEP的发生风险,并缩短住院时间。
Objective To assess the efficacy of Dachengqi decoction(DCQD)in preventing post-endoscopic retrograde cholangiopancreatography(post-ERCP)pancreatitis(PEP)in high-risk patients.Methods Patients with high-risk factors for PEP who underwent ERCP in our hospital from Dec.2021 to Jun.2023 were retrospectively enrolled.According to whether DCQD was administered after ERCP,patients were assigned to DCQD group or control group.General clinical data,endoscopic data,and the occurrence of PEP were recorded and evaluated.Results In total,60 patients with high-risk factors for PEP were enrolled,including 34 in the DCQD group and 26 in the control group.The baseline data were comparable between the 2 groups.A total of 11(18.33%)patients developed PEP,including 6(17.65%)cases in the DCQD group and 5(19.23%)cases in the control group,and there was no significant difference in the incidence of PEP between the 2 groups(P>0.05).There were 4(15.38%)cases of severe acute pancreatitis(SAP)in the control group,while no SAP occurred in the DCQD group,and the incidence of SAP in the DCQD group was significantly lower than that in the control group(P<0.05).The hospital stay of the DCQD group was(2.59±0.18)d,while the control group was(3.27±0.25)d.The hospital stay in the DCQD group was significantly shorter than that in the control group(P<0.05).Conclusion The administration of DCQD can reduce the risk of severe PEP and shorten the hospital stay after ERCP in patients with high risk factors for PEP.
作者
张汝玲
张雅婧
李清涛
赵航
ZHANG Ruling;ZHANG Yajing;LI Qingtao;ZHAO Hang(Department of Gastroenterology,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China;Department of Oncology,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)
出处
《海军军医大学学报》
北大核心
2026年第4期578-582,共5页
Academic Journal of Naval Medical University
基金
上海市级医院消化内科临床能力促进与提升专科联盟资助项目(SHDC22024302)。
关键词
内镜逆行胰胆管造影术
胰腺炎
并发症
大承气汤
预防
endoscopic retrograde cholangiopancreatography
pancreatitis
complications
Dachengqi decoction
prevention
