摘要
目的观察醒脑开窍活血方联合井穴针刺治疗血管性痴呆(VD)的临床疗效。方法将86例VD患者采用简单化分组方法分为2组,各43例,对照组予井穴针刺治疗,观察组在对照组治疗基础上予醒脑开窍活血方治疗,2组均治疗2个月。比较2组临床疗效;比较2组治疗前后精神量表(痴呆简易筛查量表、简易精神状态量表)评分、血流动力学(大脑中动脉平均血流速度、搏动指数、屏气指数)、氧化应激指标(血清超氧化物歧化酶、晚期氧化蛋白产物、谷胱甘肽过氧化物酶)、血清神经营养因子水平(血清神经调节蛋白1、神经生长因子、脑源性神经营养因子)、中医证候评分变化。结果观察组总有效率95.35%(41/43),对照组总有效率81.39%(35/43),观察组临床疗效优于对照组(P<0.05)。治疗后2组痴呆简易筛查量表评分、简易精神状态量表评分均较本组治疗前升高(P<0.05),且观察组高于对照组(P<0.05)。治疗后2组大脑中动脉平均血流速度、屏气指数均较本组治疗前升高(P<0.05),搏动指数较本组治疗前降低(P<0.05),且观察组优于对照组(P<0.05)。治疗后2组血清超氧化物歧化酶、谷胱甘肽过氧化物酶均较本组治疗前升高(P<0.05),晚期氧化蛋白产物较本组治疗前降低(P<0.05),且观察组优于对照组(P<0.05)。治疗后2组血清神经调节蛋白1、神经生长因子、脑源性神经营养因子水平均较本组治疗前升高(P<0.05),且观察组高于对照组(P<0.05)。治疗后2组痴呆健忘、腰膝酸软、肢体刺痛、头晕耳鸣评分均较本组治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。结论醒脑开窍活血方联合井穴针刺治疗VD临床疗效显著。
Objective To evaluate the clinical efficacy of Xingnao Kaiqiao Huoxue Formula combined with acupuncture at Jing points in patients with vascular dementia(VD).Methods Eighty-six patients with VD were allocated by a simple grouping method into an observation group(n=43)and a control group(n=43).The control group received acupuncture at Jing points;the observation group received the same acupuncture plus the Xingnao Kaiqiao Huoxue Formula.Both interventions continued for two months.Outcomes included overall clinical efficacy and changes from baseline in cognitive and mental status scales(dementia screening scale,Mini-Mental State Examination[MMSE]),cerebral hemodynamic parameters(mean flow velocity of the middle cerebral artery[MCA],pulsatility index[PI],breath-holding index[BHI]),oxidative stress markers(serum superoxide dismutase[SOD],advanced oxidation protein products[AOPP],glutathione peroxidase[GSH-Px]),serum neurotrophic factors(neuroregulatory protein 1,nerve growth factor[NGF],brain-derived neurotrophic factor[BDNF]),and traditional Chinese medicine(TCM)symptom scores.Results The total effective rate was 95.35%(41/43)in the observation group versus 81.39%(35/43)in the control group;the combined therapy produced superior clinical outcomes(P<0.05).Both groups showed significant post-treatment improvements in dementia screening scores and MMSE scores compared with baseline(P<0.05),with greater improvement in the observation group(P<0.05).After treatment,both groups showed significantly higher mean flow velocity of the MCA,BHI,and lower PI compared with baseline(all P<0.05),with greater improvement in the observation group(all P<0.05).Both groups presented significantly increased SOD and GSH-Px,and decreased AOPP compared with baseline(all P<0.05),and the observation group demonstrated larger gains than the control group(P<0.05).Serum levels of neurotrophic factors(neuroregulatory protein 1,NGF,BDNF)increased in both groups after treatment(P<0.05),again with higher increases in the observation group(P<0.05).TCM symptom scores for memory loss,waist/knee soreness and weakness,limb paresthesia,and dizziness/tinnitus decreased in both groups(P<0.05),with greater reductions in the observation group(P<0.05).Conclusion Xingnao Kaiqiao Huoxue Formula combined with acupuncture at Jing points appears to provide significant clinical benefit for patients with VD.
作者
李欣然
陈英华
何涛
李晨阳
李俊峰
王浩宇
孙玮
宋元毓
LI Xinran;CHEN Yinghua;HE Tao;LI Chenyang;LI Junfeng;WANG Haoyu;SUN Wei;SONG Yuanyu(Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040;Fifth Department of Acupuncture and Moxibustion,First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040)
出处
《河北中医》
2026年第4期614-618,共5页
Hebei Journal of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(编号:82074530)。
关键词
痴呆
血管性
中药疗法
针刺疗法
Vascular dementia
Traditional Chinese medicine therapy
Acupuncture therapy
