摘要
目的观察百合汤合四逆散加减治疗围绝经期女性阴虚气滞型胸痞的临床疗效。方法将60例围绝经期阴虚气滞型胸痞女性患者按照随机数字表法分为对照组和治疗组,各30例。对照组予枸橼酸莫沙必利分散片治疗,治疗组在对照组的基础上加用百合汤合四逆散汤加减治疗。2组治疗8周后统计疗效,比较2组治疗前后中医证候评分、临床症状评分(包括胸闷、食欲差、嗳气)、胃肠激素(包括胃动素、胃泌素、生长抑素、5-羟色胺)水平变化情况。结果与本组治疗前比较,2组治疗后中医证候总分均降低(P<0.05),且治疗组治疗后中医证候总分低于对照组(P<0.05)。与本组治疗前比较,2组治疗后临床症状胸闷、食欲差、嗳气评分均降低(P<0.05),且治疗组治疗后临床症状胸闷、食欲差、嗳气评分均低于对照组(P<0.05)。与本组治疗前比较,2组治疗后胃动素、胃泌素水平均升高(P<0.05),生长抑素、5-羟色胺水平均降低(P<0.05),且治疗组治疗后胃动素、胃泌素水平均高于对照组(P<0.05),生长抑素、5-羟色胺水平低于对照组(P<0.05)。治疗组总有效率90.0%(27/30),对照组总有效率66.7%(20/30),治疗组总有效率高于对照组(P<0.05)。结论百合汤合四逆散加减治疗围绝经期女性阴虚气滞型胸痞临床疗效确切,可明显改善患者中医证候和临床症状,其机制可能与调节胃肠激素水平有关。
Objective To evaluate the clinical efficacy of a modified Baihe Decoction combined with Sini powder in perimenopausal women presenting with chest oppression of the yin-deficiency and qi-stagnation pattern.Methods Sixty perimenopausal patients with chest oppression of yin-deficiency and qi-stagnation pattern were randomized by random-number table into two groups(n=30 each).The control group received oral mosapride citrate dispersible tablets,and the treatment group received the same pharmacologic therapy plus a modified Baihe Decoction combined with Sini Powder.After 8 weeks of treatment,outcomes were assessed.Evaluations included traditional Chinese medicine(TCM)syndrome scores,clinical symptom scores(chest tightness,poor appetite,belching),and serum levels of gastrointestinal hormones(motilin,gastrin,somatostatin,and 5-hydroxytryptamine).Results Both groups showed significant reductions in total TCM syndrome scores after treatment compared with baseline(P<0.05),with the treatment group achieving a significantly lower post-treatment syndrome score than the control group(P<0.05).Scores for chest tightness,poor appetite,and belching decreased significantly in both groups versus baseline(P<0.05),and the reductions were greater in the treatment group than in the control group(P<0.05).Serum motilin and gastrin levels increased,while somatostatin and 5-hydroxytryptamine levels decreased in both groups after treatment versus baseline(all P<0.05).The treatment group had higher post-treatment motilin and gastrin levels and lower somatostatin and 5-hydroxytryptamine levels than the control group(P<0.05).The overall effective rate was 90.0%(27/30)in the treatment group versus 66.7%(20/30)in the control group;the treatment group's effective rate was significantly higher(P<0.05).Conclusion A modified Baihe Decoction combined with Sini Powder demonstrated clear clinical benefit for perimenopausal women with chest oppression of yin-deficiency and qi-stagnation pattern,significantly improving both TCM syndrome measures and core clinical symptoms.The therapeutic effect may be mediated,at least in part,by modulation of gastrointestinal hormone levels.
作者
陈晶
袁广众
张天成
王磊
CHEN Jing;YUAN Guangzhong;ZHANG Tiancheng;WANG Lei(Digestive Endoscopy Center,Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province Hospital of Chinese Medicine,Nanjing,Jiangsu 210029)
出处
《河北中医》
2026年第4期575-578,582,共5页
Hebei Journal of Traditional Chinese Medicine
基金
江苏省自然科学基金青年项目(编号:BK20241150)
江苏省中医院院级课题项目(编号:Y2018CX03)。
关键词
胸痞
围绝经期
百合汤
四逆散
阴虚气滞
Chest oppression
Perimenopausal
Baihe Decoction
Sini San
Yin-deficiency and qi-stagnation pattern
