摘要
目的分析宫颈高级别鳞状上皮内瘤病变(HSIL)患者在宫颈锥切术后出现复发的影响因素。方法研究样本为中山市博爱医院2023年6月至12月120例HSIL宫颈锥切术病例,全面收集和记录入组患者临床资料,依据术后随访期间是否出现复发,划分为复发组、未复发组,通过单因素以及多因素分析复发的影响因素。结果120例HSIL宫颈锥切术患者术后均进行为期1年随访,随访期间复发者25例(20.83%),未复发者95例(79.17%)。复发组与未复发组在年龄、孕次、产次、术前人乳头瘤病毒(HPV)阳性方面比较均无统计学差异(P>0.05);复发组与未复发组在腺体受累、宫颈上皮内瘤变(CIN)分级、绝经、术后HPV阳性、吸烟史方面比较,差异有统计学意义(P<0.05)。多因素logistic回归分析显示,腺体受累、CINⅢ级、绝经、术后HPV阳性、吸烟史≥5年均是HSIL宫颈锥切术后复发的危险因素(P<0.05)。结论HSIL宫颈锥切术后患者复发的主要影响因素有腺体受累、CINⅢ级、绝经、术后HPV阳性、吸烟史≥5年,对于具有上述情况的患者需予以高度关注。
Objective To analyze the influencing factors of recurrence in patients with high-grade cervical squamous intraepithelial lesion(HSIL)after conization of cervix.Methods The research samples were 120 cases of HSIL undergoing conization of cervix in Boai Hospital of Zhongshan from June to December 2023.The data of all enrolled patients were comprehensively collected and recorded.According to whether recurrence occurred during the postoperative follow-up period,they were divided into the recurrence group and the non-recurrence group.The influencing factors of recurrence were analyzed through both univariate and multivariate analysis.Results All 120 patients undergoing conization of cervix were followed up for one year after the operation.During the follow-up,25 cases(20.83%)relapsed and 95 cases(79.17%)did not relapse.There was no statistically significant difference between the recurrence group and the non-recurrence group in terms of age,number of pregnancies,number of births,and preoperative human papilloma virus(HPV)positivity(P>0.05).There was statistically significant difference between the recurrence group and the non-recurrence group in terms of glandular involvement,cervical intraepithelial neoplasia(CIN)grade,menopause,postoperative HPV positivity,and smoking history(P<0.05).The multivariate logistic regression analysis indicated that glandular involvement,CIN gradeⅢ,menopause,positive HPV after surgery,and a smoking history of≥5 years were all risk factors for recurrence of HSIL after conization of cervix(P<0.05).Conclusion The main influencing factors for recurrence in patients with HSIL after conization of cervix include glandular involvement,CIN gradeⅢ,menopause,positive HPV after surgery,and a smoking history of≥5 years.Patients with the above conditions need to be given high attent ion.
作者
孙佳星
罗小婉
孙广范
高子轩
梁棋钧
SUN Jiaxing;LUO Xiaowan;SUN Guangfan;GAO Zixuan;LIANG Qijun(Department of Gynecology,Boai Hospital of Zhongshan,Guangdong Province,Zhongshan 528400,China)
出处
《妇儿健康导刊》
2026年第6期28-31,共4页
Journal of Women and Children's Health Guide
基金
广东省中山市医学科研项目(20231A020061)。
关键词
宫颈高级别鳞状上皮内瘤病变
复发
影响因素
宫颈锥切术
High-grade cervical squamous intraepithelial lesion
Recurrence
Influencing factor
Conization of c ervix
