摘要
目的探讨未破裂颅内动脉瘤(UIA)患者血清分泌型卷曲相关蛋白5(SFRP5)、纤维蛋白-3(Fibulin-3)的水平及临床意义。方法选取2021年9月至2024年9月于青岛市胶州中心医院收治的90例UIA患者作为UIA组,同期90例健康体检者作为对照组。采用酶联免疫吸附试验(ELISA)法检测血清SFRP5、Fibulin-3水平。采用受试者工作特征(ROC)曲线评估血清SFRP5、Fibulin-3对UIA的诊断价值;采用多因素Logistic回归分析UIA形成的影响因素。结果UIA组糖尿病、高血压、吸烟饮酒史比例高于对照组(P<0.05)。UIA组血清SFRP5水平低于对照组,Fibulin-3水平高于对照组(P<0.05)。不同动脉瘤数目、直径患者的血清SFRP5、Fibulin-3水平比较,差异有统计学意义(P<0.05)。血清SFRP5、Fibulin-3及二者联合诊断UIA的曲线下面积(AUC)分别为0.772(95%CI:0.704~0.831)、0.762(95%CI:0.693~0.822)、0.857(95%CI:0.798~0.905),联合诊断的AUC显著大于单独诊断(Z=2.353,P=0.015;Z=3.790,P<0.001)。Logistic回归分析显示,糖尿病、高血压、吸烟饮酒史、SFRP5、Fibulin-3是UIA形成的影响因素(P<0.05)。结论UIA患者血清SFRP5水平降低,Fibulin-3水平升高,二者与动脉瘤直径和数目有关,联合检测对UIA具有较高的诊断价值。
Objective To investigate the levels and clinical significance of serum secreted frizzled related protein 5(SFRP5)and fibulin-3 in patients with unruptured intracranial aneurysm(UIA).Methods Between September 2021 and September 2024,90 UIA patients in Qingdao Jiaozhou Central Hospital were included in UIA group,and 90 healthy individuals who underwent physical checkups were included in control group.Enzyme-linked immunosorbent assay(ELISA)was used to measure serum SFRP5 and Fibulin-3.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of serum SFRP5 and Fibulin-3 for UIA.Multivariate logistic regression was used to explore the influencing factors of UIA formation.Results The proportion of diabetes,hypertension,smoking and drinking history in UIA group was higher than that in control group(P<0.05).The UIA group had lower serum SFRP5,and higher serum Fibulin-3 than control group(P<0.05).Serum SFRP5 and Fibulin-3 showed statistically prominent differences among patients with different numbers and diameters of aneurysms(P<0.05).The area under curve(AUC)of serum SFRP5,Fibulin-3,and their joint value in diagnosing UIA was 0.772(95%CI:0.704~0.831),0.762(95%CI:0.693~0.822),and 0.857(95%CI:0.798~0.905)respectively.The AUC of joint diagnosis was significantly higher than that of single diagnosis(Z/P=2.353/0.015,Z/P=3.790/<0.001).Logistic regression found that diabetes,hypertension,smoking and drinking history,SFRP5,Fibulin-3 were the influencing factors of UIA formation(P<0.05).Conclusions Serum SFRP5 level is decreased and Fibulin-3 level is increased in UIA patients,which are related to the diameter and number of aneurysms.Combined detection of sFRP5 and Fibulin-3 has high diagnostic value for UIA.
作者
党庆浩
韩丽娟
刘振兴
刘文涛
张根堂
张宏泽
薛程川
DANG Qinghao;HAN Lijuan;LIU Zhenxing;LIU Wentao;ZHANG Gengtang;ZHANG Hongze;XUE Chengchuan(Department of Neurology,Qingdao Jiaozhou Central Hospital,Qingdao,Shandong 266300,China;Department of Neurosurgery,Qingdao Jiaozhou Central Hospital,Qingdao,Shandong 266300,China)
出处
《中华神经外科疾病研究杂志》
2026年第4期88-93,共6页
Chinese Journal of Neurosurgical Disease Research
基金
山东省医药卫生科技发展计划项目(202202040436)
青岛市卫生健康委项目(2022-WJZD125)。
