摘要
糖尿病肾病是糖尿病重要的微血管并发症,可进展为终末期肾病,严重威胁患者生存质量与寿命。糖尿病肾病的发病机制复杂,涵盖炎症反应、氧化应激、代谢紊乱及肾脏细胞间信号网络失衡等多重环节,并显著受到个体差异的影响。目前临床治疗手段有限,尚缺乏针对性的有效药物,给防治带来巨大挑战。本文系统综述了糖尿病肾病的发病机制和现有治疗策略,并结合最新进展探讨了新兴治疗思路与潜在突破方向,以期为创新干预手段和临床转化提供理论与实践基础。
Diabetic kidney disease is a significant microvascular complication of diabetes that can progress to end-stage renal disease,severely threatening patients'quality of life and longevity.Its pathogenesis is complex,involving multiple pathways including inflammatory responses,oxidative stress,metabolic disorders,and disrupted intercellular signaling networks in the kidney,all significantly influenced by individual variability.Current clinical treatment options remain limited,with a lack of targeted effective drugs posing substantial challenges for prevention and management.This systematic review examines the pathogenesis and existing treatment strategies for diabetic kidney disease.By integrating recent advances,it explores emerging therapeutic approaches and potential breakthrough directions,aiming to provide a theoretical and practical foundation for innovative interventions and clinical translation.
作者
赵梦雨
于萌
程阳阳
田小莲
王璐璐
蒋建东
ZHAO Meng-yu;YU Meng;CHENG Yang-yang;TIAN Xiao-lian;WANG Lu-lu;JIANG Jian-dong(Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China;HighTide Therapeutics Inc.,Shenzhen 518000,China)
出处
《药学学报》
北大核心
2026年第3期694-705,共12页
Acta Pharmaceutica Sinica
基金
中国医学科学院创新工程(2023-I2M-2-006,2024-I2M-ZH-012,2025-I2M-KJ-018)
中国工程院资助重点项目(2025-XZ-125)。
关键词
糖尿病肾病
发病机制
代谢紊乱
临床治疗
新兴疗法
diabetic kidney disease
pathogenesis
metabolic disorder
clinical treatment
emerging therapy
