摘要
动脉粥样硬化是一种慢性炎症性疾病,血管平滑肌细胞(vascular smooth muscle cell,VSMC)在其病理过程中发挥核心作用。单细胞RNA测序技术进一步揭示了VSMC在动脉粥样硬化微环境中的关键作用。动脉粥样硬化斑块微环境中的炎症因子、氧化脂质可通过多种方式影响VSMC表型转化及功能,进而影响斑块的稳定性。本文系统综述VSMC在动脉粥样硬化炎症微环境中的表型转化规律、生物学行为及其与免疫细胞的互作机制,同时对靶向VSMC-炎症轴的新型抗炎策略和模型进展进行总结,以期为动脉粥样硬化精准治疗提供理论依据和转化思路。
Atherosclerosis is a chronic inflammatory disease,and vascular smooth muscle cells(VSMC)play a central role in its pathological process.Single-cell RNA sequencing reveals the central role of VSMC in the atherosclerotic microenvironment.Inflammatory factors and oxidized lipids in the atherosclerotic plaque microenvironment affect VSMC phenotype switching and function in various ways,thereby affecting plaque stability.This article summarizes the phenotypic transformation rules,biological behaviors,and interaction mechanisms of VSMC with immune cells in the inflammatory microenvironment of atherosclerosis,and reviews the progress of new anti-inflammatory strategies and models targeting the VSMC-inflammatory axis,in order to provide a theoretical basis and translational direction for the precise treatment of atherosclerosis.
作者
谢宜芸
刘暴
XIE Yiyun;LIU Bao(Department of Vascular Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)
出处
《协和医学杂志》
北大核心
2026年第2期491-498,共8页
Medical Journal of Peking Union Medical College Hospital
基金
国家自然科学基金(82470516)
北京市自然科学基金(L248071)。
关键词
动脉粥样硬化
炎症
血管平滑肌细胞
表型转化
atherosclerosis
inflammatory
vascular smooth muscle cell
phenotype switching
