摘要
目的探讨帕金森病(PD)患者情绪加工特征及脑电图(EEG)功率值的差异性。方法选取24例PD患者为研究对象,30例健康人群为对照组。采用情绪诱导实验范式(EPIE),自我评估模型(SAM)问卷对情绪效价、唤醒度评分,EEG实时监测皮层脑电信号,比较两组不同情绪下效价、唤醒度及EEG功率值差异及相关性。结果(1)PD组BAI、BDI得分[分别为(16.92±3.83)、(22.69±2.30)]>对照组[分别为(11.62±3.65)、(14.17±4.06)],差异均有统计学意义(t值分别为4.521、7.981,均P<0.05)。(2)消极情绪下,两组效价、唤醒度差异有统计学意义(t值分别为4.505、-7.705,均P<0.05)。两组功率值在Fp1、Fp2、F7、F3、F4、T3、T4、T5处差异均有统计学意义(t值分别为-4.12、-12.43、5.76、-2.90、-4.72、-5.34、-5.81、-2.65,均P<0.05)。(3)消极情绪下,对照组效价得分与Fp1(r=-0.837,P<0.01)、Fp2(r=-0.920,P<0.01)、F4(r=-0.604,P=0.008)、P3(r=-0.658,P=0.003)、P4有相关性(r=-0.546,P=0.019),唤醒度得分与Fp1(r=0.887,P<0.01)、Fp2(r=0.958,P=0.003)、F4(r=0.683,P=0.003)、P3(r=0.721,P=0.003)、P4(r=0.610,P=0.007)有相关性;PD组效价得分与Fp2(r=-0.490,P=0.015)、F7(r=-0.564,P=0.004)有相关性,唤醒度得分与Fp2(r=0.440,P=0.031)、F7(r=0.853,P<0.01)有相关性。结论PD患者存在负性情绪加工异常,与右侧PFC及左外侧FL相关。
Objective To investigate the differences in emotional processing characteristics and electroencephalography(EEG)power values in patients with Parkinson disease(PD).Methods A total of 24 PD patients were enrolled as subjects,and 30 healthy individuals were enrolled as control group.With the use of the EPIE experimental paradigm,SAM questionnaire was used to determine the scores of emotional valence and arousal,and EEG was used for real-time monitoring of cortical EEG signals.The two groups were compared in terms of the differences in valence/arousal and EEG power values under different emotions and their correlation.Results The PD group had significantly higher BAI and BDI scores than the control group[BAI(16.92±3.83)vs(11.62±3.65),t=4.521,P<0.05;BDI(22.69±2.30)vs(14.17±4.06),t=7.981,P<0.05].In the negative mood,there were significant differences in valence/arousal between the two groups(t=4.505,-7.705,bothP<0.05).There were significant differences between the two groups in power values at Fp1,Fp2,F7,F3,F4,T3,T4,and T5(t=-4.12,-12.43,5.76,-2.90,-4.72,-5.34,-5.81,-2.65,all P<0.05).In the negative mood,for the control group,valence score was correlated with Fp1(r=-0.837,P<0.01),Fp2(r=-0.920,P<0.01),F4(r=-0.604,P=0.008),P3(r=-0.658,P=0.003),and P4(r=-0.546,P=0.019),and arousal score was correlated with Fp1(r=0.887,P<0.01),Fp2(r=0.958,P=0.003),F4(r=0.683,P=0.003),P3(r=0.721,P=0.003),and P4(r=0.610,P=0.007);for the PD group,valence score was correlated with Fp2(r=-0.490,P=0.015)and F7(r=-0.564,P=0.004),and arousal score was correlated with Fp2(r=0.440,P=0.031)and F7(r=0.853,P<0.01).Conclusion Patients with PD have negative emotional processing abnormalities associated with right PFC and left lateral FL.
作者
李佩
张霈竹
王共强
童广安
马心锋
林康
金平
韩咏竹
LI Pei;ZHANG Peizhu;WANG Gongqiang;TONG Guangan;MA Xinfeng;LIN Kang;JIN Ping;HAN Yongzhu(Institute of Neurology,Anhui University of Chinese Medicine,Hefei 230038,China;Affiliated Hospital of Neurology Institute,Anhui University of Chinese Medicine,Hefei 230061,China)
出处
《中风与神经疾病杂志》
2026年第3期259-264,共6页
Journal of Apoplexy and Nervous Diseases
基金
安徽省高校自然科学基金重点项目(2023AH050793,2024AH050969)
安徽中医药大学临床科研基金重大项目(2021sfylc04)。
关键词
帕金森病
情绪加工
脑电图
情绪诱导实验范式
Parkinson disease
Emotional processing
Electroencephalography
Emotion-inducing experimental paradigm
