摘要
弥漫性大B细胞淋巴瘤(DLBCL)是非霍奇金淋巴瘤(NHL)中最为常见的亚型,其发展机制与肿瘤微环境密切相关。脂肪酸代谢重编程是肿瘤代谢重编程的核心环节之一,在DLBCL的脂肪酸合成、摄取及β-氧化等过程中存在异常调控,不仅为肿瘤细胞快速增殖提供能量与结构物质,也会通过调控信号通路、表观遗传修饰等方式影响DLBCL的发生发展。本文梳理脂肪酸代谢酶、信号通路及微环境的作用,探索潜在诊断标志物或治疗靶点,旨在为完善DLBCL的分子机制及精准治疗提供新的思路。
Diffuse large B-cell lymphoma(DLBCL)is the most common subtype of non-Hodgkin lymphoma,and its progression is closely linked to the tumor microenvironment.Fatty acid metabolic reprogramming is one of the core aspects of tumor metabolic reprogramming.In DLBCL,abnormal regulation of fatty acid synthesis,uptake,and β-oxidation not only provides energy and structural materials for rapid tumor cell proliferation,but also influences disease initiation and progression by regulating signaling pathways and epigenetic modifications.This article reviews the roles of fatty acid metabolic enzymes,signaling pathways,and the microenvironment,and explores potential diagnostic biomarkers or therapeutic targets,aiming to provide new insights for elucidating molecular mechanisms underlying DLBCL development and advancing precise therapy.
作者
刘靖靖
李燕
LIU Jingjing;LI Yan(Graduate School of Xinjiang Medical University,Urumqi 830001;Department of Hematology,People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)
出处
《基础医学与临床》
2026年第4期582-586,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(82360040)。
关键词
弥漫性大B细胞淋巴瘤
脂肪酸代谢重编程
肿瘤代谢
肿瘤微环境
治疗靶点
diffuse large B-cell lymphoma
fatty acid metabolism reprogramming
tumor metabolism
tumor microenvironment
therapeutic targets
