摘要
子宫动脉血流动力学异常是先兆流产的重要病理基础。地屈孕酮作为一种选择性孕激素受体激动剂,除支持子宫内膜容受性外,还能显著改善子宫动脉血流参数。本文综述其潜在机制,主要包括:激活磷脂酰肌醇3-激酶/蛋白激酶B-内皮型一氧化氮合酶通路促进血管舒张,调节母胎免疫平衡以抑制炎症,以及抑制NLRP3炎症小体活化等,并探讨了地屈孕酮联合用药的协同效应及基于血流参数的个体化治疗前景,旨在为深入理解其作用机制和优化临床精准干预提供参考。
Threatened miscarriage is a common complication in early pregnancy that poses significant risks to maternal and fetal health.Uterine artery blood flow parameters have become important indicators for evaluating placental perfusion and pregnancy outcomes,with abnormal hemodynamics closely associated with an increased risk of miscarriage.As a selective progesterone receptor agonist,dydrogesterone is widely used in miscarriage prevention.It effectively reduces miscarriage risk by enhancing endometrial receptivity,regulating maternal-fetal immune balance,suppressing inflammatory responses,and optimizing uterine blood flow parameters.In addition,combination therapies involving dydrogesterone and other agents can further improve the uterine microenvironment and enhance pregnancy success rates.This review systematically summarizes the mechanisms of dydrogesterone in improving uterine hemodynamics and the progress of combination therapy research,providing a theoretical basis for clinical intervention and personalized management of threatened miscarriage.
作者
侯海倩
宋德胤
孙龙
叶新华
HOU Haiqian;SONG Deyin;SUN Long;YE Xinhua(Department of Ultrasound Medicine,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Ultrasound Medicine,Nanjing Hospital of Traditional Chinese Medicine,Nanjing 210022,China;Medical Office,Nanjing Hospital of Traditional Chinese Medicine,Nanjing 210022,China;Department of Pharmacy,Nanjing Hospital of Traditional Chinese Medicine,Nanjing 210022,China)
出处
《药学与临床研究》
2026年第1期72-76,共5页
Pharmaceutical and Clinical Research
关键词
地屈孕酮
先兆流产
子宫动脉血流
联合疗法
个体化治疗
Dydrogesterone
Threatened miscarriage
Uterine artery blood flow
Combination therapy
Personalized treatment
