摘要
目的探讨血清转录增强激活因子结构域家族成员(TEAD)1、钙黏蛋白(CDH)3、铁氧还蛋白(FDX)1水平与冠状动脉(下称冠脉)斑块稳定性及预后的关系。方法前瞻性选择2022年3月至2024年1月中国人民解放军联勤保障部队第九八八医院收治的252例冠心病患者作为观察组,根据斑块性质分为稳定斑块亚组140例和不稳定斑块亚组112例,根据随访1年是否发生心血管不良事件分为预后不良亚组45例、预后良好亚组207例。选取同期本院216名健康体检者作为对照组。比较组间及亚组间血清TEAD1、CDH3、FDX1水平。采用多因素logistic回归分析预后不良的影响因素,采用ROC曲线分析上述指标对预后的预测效能。结果观察组TEAD1、CDH3水平高于对照组,FDX1水平低于对照组;不稳定斑块亚组TEAD1、CDH3水平高于稳定斑块亚组,FDX1水平低于稳定斑块亚组,差异均有统计学意义(均P<0.05)。预后不良亚组病变血管多支占比及TEAD1、CDH3水平高于预后良好亚组,FDX1水平低于预后良好亚组,差异均有统计学意义(均P<0.05)。病变血管支数、TEAD1、CDH3、FDX1均为预后不良的独立影响因素(均P<0.05)。TEAD1、CDH3、FDX1联合预测预后不良的AUC为0.944,高于单一指标(均P<0.05)。结论血清TEAD1、CDH3和FDX1表达与冠心病患者冠脉斑块稳定性及预后相关。
Objective To explore the association of the expressions of transcriptional enhancer activator domain family member(TEAD)1,cadherin(CDH)3 and ferredoxin(FDX)1 with the stability of coronary plaques and prognosis.Methods A total of 252 patients with coronary heart disease(CHD)admitted to the 988th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army from March 2022 to January 2024 were prospectively enrolled as an observation group.They were divided into a stable plaque subgroup(140 cases)and an unstable plaque subgroup(112 cases)according to plaque features,45 patients had poor outcome(poor prognosis subgroup)and 207 patients had a good outcome(good prognosis subgroup)during 1-year follow-up,216 healthy physical examinees in the same hospital at the same time were selected as a control group.Serum TEAD1,CDH3 and FDX1 were compared between groups and subgroups.Multivariate logistic regression analysis was used to identify the influencing factors for poor prognosis.ROC curve was used to analyze the predictive efficacy of the above indicators for prognosis.Results TEAD1 and CDH3 in the observation group were higher than those in the control group,while FDX1 was lower than that in the control group;TEAD1 and CDH3 in the unstable plaque subgroup were higher than those in the stable plaque subgroup,and FDX1 was lower than that in the stable plaque subgroup,with statistically significant differences(all P<0.05).The proportion of multi-vessel lesions,TEAD1 and CDH3 were significantly higher and FDX1 was significantly lower in patients with poor prognosis subgroup than in patients with good prognosis subgroup(all P<0.05).The number of diseased vessels,TEAD1,CDH3,and FDX1 were all independent influencing factors for poor prognosis(all P<0.05).The area under the curve of the combination of TEAD1,CDH3 and FDX1 for predicting poor prognosis was 0.944,which was higher than that of a single indicator(all P<0.05).Conclusion Serum TEAD1,CDH3 and FDX1 are associated with coronary plaque stability and prognosis in CHD patients.
作者
王子暄
韩志龙
靳博闻
马会勤
WANG Zixuan;HAN Zhilong;JIN Bowen;MA Huiqin(Department of Cardiology,the 988th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army,Zhengzhou 450000,China;不详)
出处
《心电与循环》
2026年第2期156-160,共5页
Journal of Electrocardiology and Circulation
