Single-cell transcriptome profiling reveals altered neural crest cell dynamics and novel biomarkers in EDNRB mutant mice with Hirschsprung’s disease phenotype

导出

摘要 Hirschsprung’s disease(HSCR)results from neural crest cell migration and differentiation issues.1 Previously,analysis was limited to bulk tissue samples,but single-cell RNA sequencing now offers microscopic insights.Our pioneering single-cell RNA sequencing analysis of colon tissue is helping unravel HSCR’s origins and development.

作者 Minhao Sun Jafari Halima Yidan Li Jiangtian Su Ge Yang Jiajun Guo Qiwen Yang Ruihua Dang

机构地区 College of Animal Science and Technology

出处《Genes & Diseases》 2026年第1期45-48,共4页 基因与疾病(英文)

基金 supported by the National Natural Science Foundation of China(No.81770514,81270439).

关键词 bulk tissue samplesbut single cell RNA sequencing DIFFERENTIATION colon tissue neural crest cell migration HSCR biomarkers

分类号 R574.62 [医药卫生—消化系统]

引文网络
相关文献

1Jing-Zhan Zhang,Pan-Pan Zhang,Yuan Ding,Ting-Ting Li,Xiao-Jing Kang.Identification of Key Pathways and Genes Involved in Psoriasis and Vitiligo Using Bioinformatics Analysis[J].International Journal of Dermatology and Venereology,2025,8(2):83-89.
2Zipeng Cao,Yacheng Lu,Qiaoyi Yang,Anlin Luo,Shuiping Gou,Lei Zhou,Hui Li,Yanhua Wang,Tan Ding.Mapping the hidden journey of microplastics: Multi-organ deposition patterns and organ-specific health risks revealed by AI-driven analysis[J].The Innovation,2026,7(1):63-74.
3Eun-Jung Kim,Hyun-Yi Kim,Suyeon Lee,Junsu Kim,Shujin Li,Anish Ashok Adpaikar,Thantrira Porntaveetus,Senthil Kumar Baskaran,Jong-Min Lee,Han-Sung Jung.Prespecified dental mesenchymal cells for the making of a tooth[J].International Journal of Oral Science,2025,17(6):811-823.
4Xiaoting Hou,Yu Chen,Bo Zhou,Fengting Liu,Lingyun Dai,Chunbo Chen,Noah D.Carrillo,Vincent L.Cryns,Richard A.Anderson,Jichao Sun,Mo Chen.The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility[J].Protein & Cell,2025,16(10):840-857.
5Wei Zhou,Junchao Lin,Yizhuo Wang,Aqiang Fan,Liu Hong,Xiaohua Li.Bioinformatics analysis and experimental validation of m^(3)C RNA methylation regulators in hepatocellular carcinoma: expression, function, and prognostic value[J].Journal of Cancer Metastasis and Treatment,2025,11(1):351-368.
6Xiaoyu Zuo,Jinglu Zhao,Zipeng Liu,Yuxiao Yao,Dingyang Li,Xiaogang Xu,Huimin Xia,Lihua Huang,Jixiao Zeng,Yan Zhang.Integrated genomic analysis of EDNRB common and rare variants in Hirschsprung disease[J].Genes & Diseases,2026,13(2):37-40.
7Yuankai Shi,Dongqing Lv,Weineng Feng,Shuoyan Liu,Puyuan Xing,Yan Yu,Jun Yin,Xiubao Ren,Junqiang Zhang,Gaohua Han,Yongchang Zhang,Shundong Cang,Jun Chen,Enguo Chen,Lingxin Meng,Yong Zhang.A prospective, multicenter, comprehensive genomic profile signature study in patients with EGFR-mutant advanced nonsmall cell lung cancer at the first-line treatment failure of osimertinib[J].Signal Transduction and Targeted Therapy,2026,11(1):113-124.
8Bo Wu,Shuang Yang,Muhammad Tahir,Yue Ren,Yingyue Li,Ming Cao,Decang Kong,Wenhao Bo,Xiaoming Pang.Integrative metabolome and transcriptome profiling reveal key metabolic regulatory networks in Ziziphus jujuba cv.Dongzao pulp[J].Food Bioscience,2024,59(3):3927-3938.
9Andrea Rüdinger,Ömer Atmaca,Veronika Bahlinger,Elena Weisser,Sabine Matovina,Annika Rohner,Antonia Strauß,Valese Aslani,Simon Thiele,Andrea Toulouse,Tobias Haist,Annette Staebler,Sara Brucker,Falko Fend,Alois Herkommer,Stephan Reichelt.Bimodal tissue differentiation using hyperspectral imaging and elastographic Fourier transform profilometry[J].Light: Advanced Manufacturing,2025,6(4):189-202.
10Sebastian King,John Hutson.History of surgery for Hirschsprung disease:a view from Melbourne[J].World Journal of Pediatric Surgery,2025,8(2):77-79.

Genes & Diseases

2026年第1期

浏览历史

内容加载中请稍等...

Single-cell transcriptome profiling reveals altered neural crest cell dynamics and novel biomarkers in EDNRB mutant mice with Hirschsprung’s disease phenotype

相关作者

相关机构

相关主题

浏览历史