摘要
色烯并吡咯类化合物具有广泛的生理和药理活性.发展了一种CuI催化下,以1,5-二氮杂双环[4.3.0]壬-5-烯(DBN)为促进剂,室温下3-硝基色烯和环状β-烯胺酮通过[3+2]环合反应合成分子多样性2H-色烯并吡咯化合物的新方法.该反应具有良好官能团相容性、广泛底物普适性和温和反应条件等优点.
Chromeno-pyrrole derivatives exhibit a wide range of biological and pharmacological activities.Herein,a novel approach to the synthesis of molecular diversity 2H-chromeno-pyrrole has been developed from[3+2]cyclization of 3-nitrochromenes.The reaction is catalyzed by CuI with 2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidine(DBN)as the promoter at room temperature.This reaction has the advantages of good functional group compatibility,broad substrate universality,and mild reaction conditions.
作者
梁婉婷
陈思怡
徐恩琪
陈雪冰
Liang Wanting;Chen Siyi;Xu Enqi;Chen Xuebing(Yunnan Province International Joint Laboratory of Green Food(China-Vietnam),School of Chemistry and Resource Engineering,Honghe University,Mengzi,Yunnan 661199)
出处
《有机化学》
北大核心
2026年第2期496-506,共11页
Chinese Journal of Organic Chemistry
基金
云南省绿色食品中越双边国际联合实验室(No.202403AP140032)资助项目。
