摘要
目的评估甲苯磺酸瑞马唑仑在儿童小肠镜全身麻醉中的应用效果及安全性。方法前瞻性选取2023年3月至2024年3月于苏州大学附属儿童医院接受小肠镜检查的104例患儿,根据随机数字表法分为观察组与对照组,各52例,观察组采用甲苯磺酸瑞马唑仑进行全身麻醉,对照组采用丙泊酚进行全身麻醉。比较两组各项时间指标(镇静起效、麻醉、手术、拔管、苏醒)、主要生命体征(心率、平均动脉压、血氧饱和度)、改良警觉/镇静量表(MOAA/S)评分及不良事件发生率。结果观察组镇静起效时间为(44.25±4.15)s,长于对照组[(25.16±2.64)s],观察组苏醒时间为(19.31±3.13)min,短于对照组[(21.56±3.46)min],差异均有统计学意义(P<0.05)。两组麻醉时间、手术时间及拔管时间差异均无统计学意义(P>0.05)。成功置入小肠镜即刻观察组心率[(88.45±10.21)次/min]与血氧饱和度[(96.87±0.98)%]高于对照组[(81.44±9.98)次/min、(93.16±0.87)%],差异均有统计学意义(P<0.05);入室时、小肠镜操作3 min及手术结束时,两组心率与血氧饱和度差异无统计学意义(P>0.05)。两组各时点平均动脉压及镇静MOAA/S评分比较,差异均无统计学意义(P>0.05)。不良反应方面,观察组低血压、注射痛发生率分别为11.54%、5.77%,低于对照组(28.85%、46.15%),差异均有统计学意义(P<0.05)。结论甲苯磺酸瑞马唑仑在儿童小肠镜全身麻醉中的应用效果显著,具有苏醒更快,血流动力学更稳定,且低血压及注射痛不良反应发生率较低的优势。
Objective To evaluate the efficacy and safety of remimazolam tosilate for general anesthesia in pediatric enteroscopy.Methods A total of 104 children who underwent enteroscopy in Children's Hospital Affiliated to Soochow University from March 2023 to March 2024 were prospectively selected.According to the random number table method,the subjects were divided into the observation group and the control group,52 cases in each group.The observation group was given general anesthesia with remazolam tosylate,and the control group was given general anesthesia with propofol.The time indicators(sedation onset,anesthesia,surgery,extubation,recovery),main vital signs(heart rate,mean arterial pressure,blood oxygen saturation),modified alertness/sedation scale(MOAA/S)score and the incidence of adverse events were compared between the two groups.Results The sedation onset time of the observation group was(44.25±4.15)s,which was longer than that of the control group[(25.16±2.64)s],the recovery time of the observation group was(19.31±3.13)min,which was shorter than that of the control group[(21.56±3.46)min],and the differences were statistically significant(P<0.05).The heart rate[(88.45±10.21)times/min]and blood oxygen saturation[(96.87±0.98)%]in the observation group were higher than those in the control group[(81.44±9.98)times/min,(93.16±0.87)%],the differences were statistically significant(P<0.05).There was no statistically significant difference in mean arterial pressure and sedation MOAA/S score between the two groups at each time point(P>0.05).In terms of adverse reactions,the incidences of hypotension and injection pain in the observation group were 11.54%and 5.77%,respectively,which were lower than those in the control group(28.85%and 46.15%),and the differences were statistically significant(P<0.05).Conclusion Remimazolam tosilate demonstrates favorable efficacy in general anesthesia for pediatric enteroscopy,with advantages of faster recovery,more stable hemodynamics,and lower incidence of hypotension and injection pain compared with propofol.
作者
曹明珠
王谦
唐然
高珊珊
陈佳伟
涂兆珍
CAO Mingzhu;WANG Qian;TANG Ran(Department of Anesthesiology,Children's Hospital Affiliated to Soochow University,Suzhou Jiangsu 215000)
出处
《临床和实验医学杂志》
2026年第4期446-448,F0003,共4页
Journal of Clinical and Experimental Medicine
基金
江苏省自然科学基金面上项目(编号:BK20241800)。
