摘要
妊娠期高血压疾病并发不典型溶血尿毒综合征(aHUS)临床罕见且病情危重,早期识别与干预对改善预后至关重要。本文报告2例子痫前期产后发生aHUS的患者,均表现为血小板计数急剧下降、微血管病性溶血及急性肾损伤。病例1因未及时行外周血涂片致诊断延迟,病例2早期识别并立即处理;2例患者确诊后均接受血浆置换及肾脏替代治疗,最终病情缓解出院。对于妊娠期高血压疾病合并血小板计数下降及肾功能损害的患者,应尽早行外周血涂片检查,若见破碎红细胞需高度警惕aHUS并及时启动血浆置换,以阻断器官功能损伤。
Hypertensive disorders of pregnancy complicated with atypical hemolytic uremic syndrome(aHUS)are clinically rare and the condition is critical,and early recognition and intervention are crucial for improving prognosis.This article reports two cases of patients who developed aHUS after preeclampsia,both presenting with a sharp decline in platelets,microangiopathy hemolysis,and acute kidney injury.Case one was diagnosed with a delay due to the failure to perform peripheral blood smear in time,while case two was identified early and treated immediately;and both patients received plasma exchange and renal replacement therapy after diagnosis and were eventually discharged after their conditions improved.For patients with hypertensive disorders of pregnancy complicated with thrombocytopenia and renal function impairment,peripheral blood smear examination should be performed as soon as possible.If broken red blood cells are seen,aHUS should be highly vigilant and plasma exchange should be initiated promptly to prevent organ function damage.
作者
林青
赵栋
蔡昱
LIN Qing;ZHAO Dong;CAI Yu(Department of Critical Care Medicine,Beijing Tongren Hospital,Capital Medical University,Beijing 100176,China;Department of Obstetrics and Gynecology,Beijing Tongren Hospital,Capital Medical University,Beijing 100176,China)
出处
《中国医药导报》
2026年第5期113-116,共4页
China Medical Herald
基金
首都医科大学本科生科研创新项目(XSKY2023)。
