摘要
目的:探讨小儿EB病毒(EBV)感染合并肺炎支原体肺炎(MPP)的Logistic回归模型建立及防控策略分析。方法:收集2019年9月~2023年9月在江苏省中医院治疗的EBV感染合并MPP患儿的临床资料。共收集符合排纳标准的有效病例患儿228例,根据EBV感染是否合并MPP分为MPP组(58例)和非MPP组(170例)。收集和分析受试者资料,用单因素及Logistic回归分析筛选EBV感染是否合并MPP的影响因素并验证其预测效能。结果:多因素Logistic回归分析显示,发热热程长(OR=1.438,95%CI:1.075~1.925),CRP(OR=1.274,95%CI:1.064~1.526)、IgM(OR=1.023,95%CI:1.005~1.042)、IgG(OR=1.004,95%CI:1.001~1.006)、AST(OR=1.120,95%CI:1.051~1.193)、ALT(OR=1.086,95%CI:1.029~1.145)高表达水平均是EBV感染合并MPP的危险因素(P<0.05);基于此建立的预警模型的AUC=0.829(95%CI:0.774~0.876)。结论:发热热程、CRP、IgM、IgG、AST、ALT是小儿EBV感染合并MPP的危险因素,针对其危险因素制定有效的防控策略可以降低小儿EBV感染合并MPP的发生率。
Objective:To investigate the prevention and control measures foREpstein-BarRvirus(EBV)infection concomitant with Mycoplasma pneumonia pneumonia(MPP)in youngeRchildren based on logistic regression model analysis.Methods:The clinical data were collected in the youngeRchildren combined EBV with MPP infection treated in ouRhospital between SeptembeR2019 and SeptembeR2023.In total,228 eligible cases were included,and divided into a MPP-infected group(n=58)and a non-MPP-infected group(n=170)according to the presence of EBV concomitant with MPP infection.The data were then retrieved from the subjects included,and analyzed.One-way and logistic regression analyses were performed to screen foRthe factors affecting presence of EBV combined with MPP infection,and the predictive efficacies were verified.Results:Multivariate logistic regression analysis showed that long duration of feveR(OR=1.438,95%CI:1.075-1.925),highly expressed levels of C-reactive protein(CRP)(OR=1.274,95%CI:1.064-1.526),IgM(OR=1.023,95%CI:1.005-1.042),IgG(OR=1.004,95%CI:1.001-1.006),AST(OR=1.120,95%CI:1.051-1.193),and ALT(OR=1.086,95%CI:1.029-1.145)were all risk factors foREBV concomitant with MPP infection(P<0.05).The area undeRthe curve(AUC)foRthe early warning model established on these factors basis was 0.829(95%CI:0.774-0.876).Conclusion:FeveRduration,higheRlevels of CRP,IgM,IgG,AST and ALT are risk factors foREBV concomitant with MPP in youngeRchildren.The prevention and control measures developed on these risks basis can effectively reduce the incidence of such infection in the children.
作者
芮隽
孔飞
RUI Jun;KONG Fei(Department of Pediatrics,Affiliated Hospital of Nanjing University of Chinese Medicine(Jiangsu Provincial Hospital of Traditional Chinese Medicine),Nanjing 210029,Jiangsu,China)
出处
《皖南医学院学报》
2026年第1期55-57,79,共4页
Journal of Wannan Medical College
基金
江苏省中医药科技发展计划项目(YB202006)。
关键词
小儿
EB病毒
支原体肺炎
LOGISTIC回归模型
防控策略
youngeRchildren
Epstein-BarRvirus
Mycoplasma pneumonia pneumonia
Logistic regression model
prevention and control strategies
