摘要
目的观察盐酸多奈哌齐联合奥拉西坦在老年痴呆患者治疗中的实际效用,同时评估其对患者认知水平及日常生活能力的影响。方法选取82例老年痴呆患者,随机抽签分为对照组(采取奥拉西坦治疗)与观察组(应用奥拉西坦与盐酸多奈哌齐联合治疗),各41例。对比两组治疗效果、治疗前后简易精神状态检查量表(MMSE)评分、治疗前后日常生活活动能力评定量表(ADL)评分、不良反应发生率。结果观察组治疗总有效率95.12%相比于对照组的80.49%明显较高(P<0.05)。治疗3、6个月,观察组MMSE评分(22.80±1.78)、(25.49±2.12)分相比于对照组的(18.92±1.60)、(21.03±1.74)分明显较高(P<0.05)。治疗3、6个月,观察组ADL评分(50.12±4.68)、(64.27±5.83)分相比于对照组的(42.57±3.51)、(52.11±4.27)分明显较高(P<0.05)。观察组不良反应发生率相较于对照组明显更低(4.88%vs.19.51%)(P<0.05)。结论老年痴呆患者在联合应用盐酸多奈哌齐与奥拉西坦后,其精神状态得到显著提升,认知功能明显增强,日常生活自理能力也得到了有效改善,同时该药物治疗过程中产生的不良反应相对较少,疗效安全显著。
Objective To observe the practical effect of donepezil hydrochloride in the treatment of elderly patients with Alzheimer's Disease,and evaluate its impact on cognitive level and daily living ability of patients.Methods A total of 82 patients with Alzheimer's disease were selected as samples for this study,and divided into control group(treated with oxiracetam)and observation group(combination therapy of oxiracetam and donepezil hydrochloride)by random lottery method,with 41 cases in each group.A comparative study was conducted on two groups of subjects to observe differences in treatment effects,analyze changes in Mini-Mental State Examination(MMSE)scores and fluctuations in Activities of Daily Living(ADL)scores before and after treatment,as well as the incidence of adverse reactions in both groups.Results The data showed that the overall treatment effectiveness rate in the observation group was 95.12%,significantly higher than that in the control group(80.49%),with statistical significance(P<0.05).At 3 and 6 months after treatment,the MMSE scores of the observation group were(22.80±1.78)and(25.49±2.12)points,which were significantly higher than those of the control group[(18.92±1.60)and(21.03±1.74)points](P<0.05).At 3 and 6 months after treatment,the ADL scores of the observation group were(50.12±4.68)and(64.27±5.83)points,which were significantly higher than those of the control group[(42.57±3.51)and(52.11±4.27)points](P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(4.88%vs.19.51%)(P<0.05).Conclusion The use of donepezil hydrochloride and oxiracetam in the intervention treatment of elderly patients with Alzheimer's disease can significantly improve their mental state,enhance cognitive function,and improve their daily self-care ability.Additionally,this medication produces relatively few adverse reactions during treatment,offering a safe and effective therapeutic outcome.
作者
杨琳
YANG Lin(Liaoyang Central Hospital,Liaoyang 111000,China)
出处
《中国现代药物应用》
2026年第8期88-91,共4页
Chinese Journal of Modern Drug Application
关键词
老年痴呆
盐酸多奈哌齐
奥拉西坦
认知水平
生活能力
Alzheimer's disease
Donepezil hydrochloride
Oxiracetam
Cognitive level
Living ability
