摘要
目的:评估针刺养老穴联合基础治疗对原发性干燥综合征(PSS)相关干眼症的疗效、安全性及即时效应。方法:将66例本病患者按随机数字表法分为对照组和观察组,每组33例。对照组行常规西医基础治疗,观察组在对照组基础上,加用针刺养老穴治疗,每2周1次,共7次。主要观察指标为眼干视觉模拟评分法(VAS)评分,并据此评估临床疗效;次要指标包括干燥综合征患者自我报告指数(ESSPRI)、中医证候积分、非接触式泪膜破裂时间(NIBUT)、希尔默试验(SIt)、针刺起效及维持时间、实验室指标[红细胞沉降率(ESR)、C反应蛋白(CRP)、免疫球蛋白(IgA、IgG、IgM)]、不良反应发生率。结果:治疗后,两组眼干VAS评分均降低,且观察组低于对照组(均P<0.05),观察组疗效优于对照组(P<0.05);治疗后两组ESSPRI评分及中医证候积分均较治疗前降低,且观察组低于对照组(P<0.05);治疗后两组NIBUT均较治疗前延长,且观察组长于对照组(均P<0.05);治疗后两组SIt结果均较治疗前改善(P<0.05),但组间比较差异无统计学意义(P>0.05);观察组首次针刺起效时间(4.85±3.27)min,疗效维持时间随针刺次数增加呈逐步延长趋势(P<0.05);治疗后两组实验室指标均未见明显变化,组间比较差异均无统计学意义(P>0.05);两组均未发生严重不良反应。结论:针刺养老穴联合基础治疗可显著改善PSS相关干眼症,具有起效快、维持时间逐渐延长的特点,且安全性良好。
Objective:To evaluate the efficacy,safety,and immediate effects of acupuncture at Yanglao acupoint(SI6)combined with basic treatment on dry eye syndrome associated with primary Sjögren’s syn⁃drome(PSS).Methods:A total of 66 patients with this disease were randomly divided into the control group and the observation group,with 33 cases in each group.The control group received conven⁃tional Western medicine basic treatment,while the observation group was treated with acupuncture at Yanglao acupoint in addition to the treatment in the control group,once every two weeks for a total of seven sessions.The main observation indicators were the visual analogue scale(VAS)score for dry eye,and the clinical efficacy was evaluated based on this;the secondary indicators included the EULAR Sjögren’s syndrome patients reported index(ESSPRI),traditional Chinese medicine(TCM)syndrome score,noninvasive tear film breakup time(NIBUT),Schirmer test(SIt),the onset and maintenance time of acupuncture,laboratory indicators[erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),immunoglobulins(IgA,IgG,IgM)],and the incidence rate of adverse reactions.Results:After treatment,the VAS score for dry eyes in both groups decreased,and those in the observation group were lower than those in the control group(all P<0.05).The efficacy of the observation group was superior to that of the control group(P<0.05).After treatment,the ESSPRI scores and TCM syndrome scores of both groups decreased compared to those before treatment,and those in the observation group were lower than those in the control group(P<0.05).After treatment,the NIBUT of both groups was longer than that before treatment,and that of the observation group was longer than that of the control group(all P<0.05).After treatment,the SIt results of both groups improved compared to those before treatment(P<0.05),but there was no statistically significant difference between the groups(P>0.05).The onset time of the first acupuncture effect in the observation group was(4.85±3.27)minutes,and the duration of the therapeutic effect showed a gradually prolonged trend with the increase in the number of acupuncture sessions(P<0.05).After treatment,no significant changes were observed in the laboratory indicators of both groups,the differences between groups were not statistically significant(P>0.05).There were no serious adverse reactions in both groups.Conclusion:Acupuncture at Yanglao acupoint combined with basic treatment can significantly alleviates PSS-related dry eye syndrome,with the characteristics of rapid onset,progressively prolonged maintenance effects,and good safety.
作者
邓世欣
刘承罡
王骁
DENG Shixin;LIU Chenggang;WANG Xiao(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200030,China)
出处
《山东中医杂志》
2026年第3期277-282,306,共7页
Shandong Journal of Traditional Chinese Medicine
基金
上海市进一步加快中医药传承创新发展三年行动计划[编号:ZY(2021-2023)-0202]。
关键词
原发性干燥综合征
干眼症
针刺
养老穴
primary Sjögren’s syndrome
dry eye syndrome
acupuncture
Yanglao acupoint
