摘要
目的探讨同型半胱氨酸(Hcy)联合那不勒斯预后评分(NPS)对脑梗死共病高血压患者预后的预测价值。方法选取2024年8月至10月华北理工大学附属医院神经内科收治的412例脑梗死共病高血压患者作为研究对象。收集其临床资料,根据随访6个月改良Rankin量表评分分为预后良好组和预后不良组,分析预后的影响因素。通过受试者操作特征曲线分析Hcy联合NPS对脑梗死共病高血压患者预后不良的预测价值。结果412例脑梗死共病高血压患者中141例患者发生预后不良,预后不良发生率为34.2%。两组年龄、红细胞计数、淋巴细胞计数、中性粒细胞计数、Hcy、白蛋白、肌力分级、NPS比较,差异有统计学意义(P<0.05)。Hcy、肌力分级、NPS是脑梗死共病高血压患者预后不良的影响因素(P<0.05)。Hcy联合NPS预测脑梗死共病高血压患者预后不良的预测效能优于Hcy、NPS单独预测(P<0.01)。结论Hcy、NPS是脑梗死共病高血压患者预后的影响因素,两项指标联合预测对脑梗死共病高血压患者预后具有良好的预测能力。
Objective To investigate the predictive value of homocysteine(Hcy)combined with Naples prognostic score(NPS)for the prognosis of patients with cerebral infarction complicated by hypertension.Methods A total of 412 patients with cerebral infarction complicated by hypertension,admitted to the Department of Neurology of North China University of Science and Technology Hospital from August to October 2024 were selected as the study subjects,and their clinical data were collected.Based on the modified Rankin scale scores at a 6-month follow-up,the patients were divided into good prognosis group and poor prognosis group.Factors influencing prognosis were analyzed.The predictive value of Hcy combined with the NPS for the poor prognosis of patients with cerebral infarction complicated by hypertension was assessed using receiver operating characteristic curve analysis.Results Among 412 patients with cerebral infarction complicated with hypertension,141 patients had a poor prognosis,with an incidence of poor prognosis of 34.2%.There were statistically significant differences in age,red blood cell count,lymphocyte count,neutrophil count,Hcy,albumin,muscle strength grading,and NPS between the two groups(P<0.05).Hcy,muscle strength grading,and NPS were the influencing factors for poor prognosis in patients with cerebral infarction complicated with hypertension(P<0.05).The predictive efficacy of Hcy combined with NPS in predicting the poor prognosis of patients with hypertension complicated by cerebral infarction was superior to that of Hcy and NPS alone(P<0.01).Conclusion Hcy and NPS are the influencing factors for the prognosis of patients with cerebral infarction complicated with hypertension.The combined prediction of the two indicators has a good predictive ability for the prognosis of patients with cerebral infarction complicated with hypertension.
作者
李起起
李尤凡
王尚书
郝习君
郭全荣
LI Qiqi;LI Youfan;WANG Shangshu;HAO Xijun;GUO Quanrong(School of Nursing and Rehabilitation,North China University of Science and Technology,Hebei Province,Tangshan 063210,China;Department of Otorhinolaryngology,North China University of Science and Technology Hospital,Hebei Province,Tangshan 063000,China)
出处
《中国医药导报》
2026年第6期54-58,共5页
China Medical Herald
基金
河北省医学科学研究课题(20250162)
河北省重点研发计划卫生健康创新专项项目(22377758D)。
关键词
脑梗死
高血压
同型半胱氨酸
那不勒斯预后评分
预测
Cerebral infarction
Hypertension
Homocysteine
Naples prognosis score
Predictive
