摘要
目的探讨复方谷氨酰胺肠溶胶囊联合双歧杆菌乳杆菌三联活菌片治疗肠易激综合征(IBS)的疗效及对肠道菌群、脑肠轴相关血清指标的影响。方法选取2022年3月至2024年3月成都市郫都区人民医院收治的IBS患者86例,采用随机数表法将患者分为对照组(43例,复方谷氨酰胺肠溶胶囊治疗)与研究组(43例,复方谷氨酰胺肠溶胶囊联合双歧杆菌乳杆菌三联活菌片治疗),疗程均为4周。分别于治疗前及治疗4周后完成患者临床量表评分、肠道菌群及相关实验室检查指标检测。比较两组疗效与不良反应发生情况。结果研究组患者治疗总有效率为93.02%,显著高于对照组的76.74%(P<0.05)。治疗后,两组患者血清血管活性肠肽、降钙素基因相关肽、5-羟色胺与神经肽Y水平均显著下降,且研究组均低于对照组(P<0.05)。治疗后,研究组IBS症状严重程度量表评分、大肠埃希菌丰度显著低于对照组,乳酸杆菌与双歧杆菌丰度显著高于对照组(P<0.05)。治疗后,两组患者血清白细胞介素(IL)6、IL-17A水平均显著下降(P<0.05),IL-10水平显著上升(P<0.05);且治疗后,研究组血清IL-6、IL-17A水平均显著低于对照组,IL-10水平显著高于对照组(P<0.05)。两组患者用药期间均未发生明显不良反应及肝肾功能异常、过敏反应等严重不良事件。结论复方谷氨酰胺肠溶胶囊联合双歧杆菌乳杆菌三联活菌片治疗IBS安全有效,可有效改善肠道菌群,调控脑肠轴-炎症相关指标。
Objective To explore the efficacy of compound glutamine enteric-coated capsules combined with live combined bifidobacterium and lactobacillus tablets in the treatment of irritable bowel syndrome(IBS)and its effects on intestinal flora and serum indicators related to the brain-gut axis.Methods A total of 86 IBS patients admitted to the People's Hospital of Pidu District,Chengdu from March 2022 to March 2024 were randomly divided into a control group(n=43,compound glutamine enteric-coated capsules)and a study group(n=43,compound glutamine enteric-coated capsules combined with live combined bifidobacterium and lactobacillus tablets).The treatment course for both groups was 4 weeks.Clinical scale scores,intestinal flora,and related laboratory indicators were measured before and after 4 weeks of treatment.The efficacy and incidence of adverse reactions were compared between the two groups.Results The total effective rate in the study group was 93.02%,which was higher than that in the control group(76.74%)(P<0.05).After treatment,the IBS Symptom Severity Scale score and the abundance of Escherichia coli in the study group were lower than those in the control group,while the abundances of Lactobacillus and Bifidobacterium were higher than those in the control group(all P<0.05).After treatment,the serum levels of vasoactive intestinal peptide,calcitonin gene-related peptide,5-hydroxytryptamine and neuropeptide Y in both groups decreased significantly,and those in the study group were all lower than those in the control group(P<0.05).After treatment,serum interleukin(IL)-6 and IL-17A levels significantly decreased in both groups(P<0.05),while IL-10 levels significantly increased(P<0.05).Moreover,after treatment,the study group showed lower serum IL-6 and IL-17A levels and a higher IL-10 level compared with the control group(P<0.05).No obvious adverse reactions,liver or kidney dysfunction,allergic reactions,or other serious adverse events occurred in either group during treatment.Conclusion Compound glutamine enteric-coated capsules combined with live combined bifidobacterium and lactobacillus tablets are safe and effective in treating IBS.This combination can effectively improve intestinal flora and regulate brain-gut axis-inflammation related indicators.
作者
徐泽艳
徐静
赖敏
陈文静
XU Zeyan;XU Jing;LAI Min;CHEN Wenjing(Department of Gastroenterology,Chengdu Pidu District People's Hospital,Chengdu 611730,China)
出处
《转化医学杂志》
2026年第3期496-500,共5页
Translational Medicine Journal
基金
四川省中医药管理局科研项目(2023MS250)。
关键词
肠易激综合征
复方谷氨酰胺肠溶胶囊
双歧杆菌乳杆菌三联活菌片
肠道菌群
脑肠轴
irritable bowel syndrome
compound glutamine enteric-coated capsule
live combined bifidobacterium and lactobacillus tablet
intestinal flora
brain-gut axis
