摘要
纳米二氧化钛(TiO_(2))凭借其优异的紫外线屏蔽性、抗菌性及光学透明性,在防晒霜、粉底等化妆品中广泛应用,但其纳米特性引发的透皮迁移、光催化活性及吸入风险,与复杂基质导致的检测难题,共同制约着安全性评估体系与检测方法的深入完善。当前对纳米二氧化钛的研究重点聚焦于开发精准高效的检测技术以突破行业瓶颈,近年来,随着分析技术的不断进步,已开发了多种检测方法,实现了对化妆品中的纳米二氧化钛进行粒径、形貌及含量的精准分析。本文系统综述了检测化妆品中纳米二氧化钛颗粒的前处理技术、粒径表征方法及定量分析手段的研究进展,探讨了不同技术的优势与局限性,未来需进一步优化检测灵敏度、开发更便捷科学的检测方法,以应对复杂化妆品基质的挑战,为纳米材料的安全评估提供可靠支持。
Nanoparticulate titanium dioxide(TiO_(2))is widely used in cosmetics such as sunscreens and foundations due to its excellent UV-blocking capacity,antibacterial,and optical transparency properties.However,its nanoscale properties,such as transdermal migration potential,photocatalytic activity,and inhalation risks,combined with the analytical challenges arising from complex cosmetic matrices,have hindered advancements in safety assessment protocols and detection methodologies.Current research efforts prioritize the development of precise and efficient detection technologies for nanoparticulate TiO_(2)to address key technical limitations.Recent advancements in analytical techniques have enabled comprehensive characterization of nanoparticulate TiO_(2)in cosmetics,including particle size distribution,morphological features and content quantification.The pretreatment protocols,particle size characterization methods,and quantification strategies for nanoparticulate TiO_(2)in cosmetics were systematically reviewed,critically evaluating the merits and constraints of existing technologies.To address the challenges posed by complex cosmetic matrices,future efforts should focus on enhancing detection sensitivity and developing standardized analytical workflows,which will establish robust frameworks for nanomaterial safety assessment.
作者
庞学斌
曹菲斐
邱颖姮
何春叶
王晓炜
PANG Xuebin;CAO Feifei;QIU Yingheng;HE Chunye;WANG Xiaowei(Shenzhen Institute for Drug Control,NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics,Guangdong Shenzhen 518057,China)
出处
《广州化工》
2026年第5期22-25,共4页
GuangZhou Chemical Industry
基金
广东省药品监督管理局科技创新团队项目(2022TDB65)。
关键词
纳米二氧化钛
检测方法
化妆品安全
表征技术
监管框架
nanoparticulate titanium dioxide
detection methods
cosmetic safety
characterization techniques
regulatory frameworks
