摘要
目的:分析2012~2022年杭州市上城区恶性肿瘤流行及变化趋势。方法:根据2012~2022年杭州市上城区肿瘤登记报告数据,结合人口学资料,计算上城区恶性肿瘤发病率和顺位指标,以2000年中国标准人口构成为标准,计算标化发病率,即中标率,应用Joinpoint回归模型计算平均年度变化百分比(average annual percent change,AAPC)分析恶性肿瘤流行趋势。结果:2012~2022年杭州市上城区恶性肿瘤发病率为486.92/10万,中标率为272.62/10万,其中男性恶性肿瘤的发病率和中标率为499.16/10万和257.02/10万,女性恶性肿瘤的发病率和中标率为474.94/10万和293.72/10万。恶性肿瘤发病率在40岁之后上升趋势明显。上城区主要的发病癌种有肺癌、甲状腺癌、女性乳腺癌、结直肠癌和胃癌。趋势分析结果显示,女性恶性肿瘤中标率呈现上升趋势(AAPC=2.31%,P=0.009)。前5顺位高发恶性肿瘤中,肺癌和胃癌上升趋势显著(中标率:AAPC分别为11.97%和4.28%),分性别看,男性肺癌(中标率:AAPC=11.82%,P<0.001)和前列腺癌(中标率:AAPC=11.84%,P<0.001)呈现逐年上升趋势,女性肺癌(中标率:AAPC=20.95%,P<0.001)和结直肠癌(中标率:AAPC=14.34%,P=0.016)呈现逐年上升趋势。结论:上城区恶性肿瘤疾病负担仍然较重,肺癌、甲状腺癌、女性乳腺癌、结直肠癌和胃癌是上城区居民健康的主要威胁,40岁以上人群是肿瘤防控的重点干预对象。对男性的前列腺癌和女性的乳腺癌要加大早期筛查力度。
Objective:To analyze the prevalence and trends of malignant tumors in Shangcheng District,Hangzhou,from 2012 to 2022.Methods:Using tumor registry data and demographic information for Shangcheng District,Hangzhou from 2012 to 2022,the incidence and ranking of malignant tumors were calculated.The incidence rate and age-standardized incidence rate by Chinese standard population in 2000(ASRC)were calculated.Joinpoint regression analysis was performed to calculate the average annual percent change(AAPC)to explore trends in the incidence of malignant tumors in Shangcheng District.Results:During 2012~2022 in Shangcheng District,the crude incidence(per 100,000)of malignant tumors was 486.92 overall,499.16 for males,and 474.94 for females.The ASRC were 272.62,257.02,and 293.72 per 100,000,respectively.The incidence of malignant tumors increased significantly after the age of 40.In Shangcheng District,the most common cancers were lung caner,thyroid cancer,breast cancer in women,colorectal cancer and stomach cancer.A significant rising trend in malignant tumor incidence was observed among women(ASRC:AAPC=2.31%,P=0.009).Analysis of the top five malignant tumors showed a significant upward trend in lung cancer(AAPC=11.97%)and stomach cancer(AAPC=4.28%).Gender-specific analysis revealed that lung cancer(ASRC:AAPC=11.82%,P<0.001)and prostate cancer(ASRC:AAPC=11.84%,P<0.001)in males increased,while lung cancer(ASRC:AAPC=20.95%,P<0.001)and colorectal cancer(ASRC:AAPC=14.34%,P=0.016)in females demonstrated consistent annual growth.Conclusion:The disease burden of cancer in Shangcheng District was still heavy,with lung cancer,thyroid cancer,breast cancer(in women),colorectal cancer,and stomach cancer constituting the main threats to residents'health.Cancer prevention efforts should focus on adults over 40,with intensified early screening for prostate cancer in men and breast cancer in women.
作者
施明明
王慧
张晓
Shi Mingming;Wang Hui;Zhang Xiao(Department of Chronic Disease Prevention and Control,Shangcheng District Center for Disease Control and Prevention(i.e.Shangcheng District Health Inspection Institute),Hangzhou 310001,Zhejiang,China;Affiliated Hangzhou First People's Hospital,School of Medicine,Westlake University,Hangzhou 310014,Zhejiang,China)
出处
《肿瘤预防与治疗》
2026年第1期36-42,共7页
Journal of Cancer Control And Treatment
基金
杭州市卫生科技计划一般项目(编号:B20241537)。
