摘要
吸湿研究一直以来都是中药关注的重点和热点,吸湿机制的阐明对于制剂处方、工艺优化及贮藏条件选择等具有重要作用。吸湿模型是表征中药吸湿机制重要手段,种类较多。双指数模型是基于物质能量守恒定律和费克扩散第一定律对中药提取物物性特点构建的动力学数学模型。近年来,该模型广泛应用于模拟中药提取物和固体制剂在不同湿度环境下的动态吸湿行为,揭示了中药吸湿动力学参数与物料特性的关联规律,为中药吸湿行为表征提供了新视角。该文系统综述此模型在中药领域的应用进展,并分析该模型在中药领域应用优缺点及面临的挑战,展望了该模型在其他领域应用趋势,旨在为中药吸湿机制阐明和中药防潮技术研究提供参考,也为其在食品和高分子材料等方面推广应用提供借鉴。
Hygroscopicity research has long been a key focus and hot topic in Chinese materia medica(CMM).Elucidating hygroscopic mechanisms plays a vital role in formulation design,process optimization,and storage condition selection.Hygroscopic models serve as essential tools for characterizing CMM hygroscopic mechanisms,with various types available.The double exponential model is a kinetic mathematical model constructed based on the law of conservation of energy and Fick's first law of diffusion,tailored to the physical properties of CMM extracts.In recent years,this model has been extensively applied to simulate the dynamic moisture absorption behavior of CMM extracts and solid dosage forms under varying humidity conditions.It has revealed the correlation between moisture absorption kinetic parameters and material properties,offering a new perspective for characterizing the moisture uptake behavior of CMM.This paper systematically reviews the application progress of this model in the field of CMM,analyzes its advantages,disadvantages,and challenges in this domain,and explores its potential application trends in other fields.It aims to provide references for elucidating the moisture absorption mechanisms of CMM and researching moisture-proofing technologies,while also offering insights for its broader application in food and polymer materials.
作者
余艳婷
熊磊
何雁
刘微
杨婧
张尧
陈佳莉
罗晓健
饶小勇
YU Yanting;XIONG Lei;HE Yan;LIU Wei;YANG Jing;ZHANG Yao;CHEN Jiali;LUO Xiaojian;RAO Xiaoyong(Jiangxi University of Chinese Medicine,Nanchang 330004,China;Jiangxi Provincial Drug Certification and Evaluation Center,Nanchang 330046,China;National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine,Nanchang 330006,China)
出处
《中国实验方剂学杂志》
北大核心
2026年第5期340-346,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
江西省主要学科和技术带头人培养计划——领军人才项目(20204BCJ22032)
国家自然科学基金项目(30860382,82060715)
江西省高等学校大学生创新创业训练计划项目(202510412253)。
关键词
双指数模型
中药
吸湿
动力学模型
提取物
固体制剂
double exponential model
Chinese materia medica
moisture absorption
kinetic models
extracts
solid preparations
