摘要
以尼铂金甲酯和丙烯酸甲酯为原料,在有机碱催化下发生迈克尔加成(Michael Addition)反应,合成了4-(3-酯基氧代丙基)苯甲酸甲酯。通过分离提纯,原料尼铂金甲酯和丙烯酸甲酯的回收率分别达到90%和87%,产物的综合收率接近90%。考察了催化剂类型、催化剂用量、反应时间及反应温度对反应过程中原料尼铂金甲酯转化率的影响,进一步对反应的适用性进行了扩展,探究了苯酚衍生物苯环上不同取代基对该反应的影响。结果表明,当以甲醇钠为催化剂、用量为酚类衍生物的10%、反应温度为80℃、反应时间为12 h时可得到较好的转化率,且在成本上相对友好。
Using methyl 4-hydroxybenzoate and methyl acrylate as raw materials,a Michael Addition reaction was carried out under the catalysis of organic bases to synthesize methyl 4-(3-esteroxypropyl)benzoate.Through separation and purification,the recovery rate of raw materials methyl 4-hydroxybenzoate and methyl acrylate reached 90%and 87%respectively,and the comprehensive yield of the product was close to 90%.The effects of catalyst type,catalyst dosage,reaction time and reaction temperature on the conversion rate of raw materials methyl 4-hydroxybenzoate during the reaction were investigated.The applicability of the reaction was further expanded by exploring the influence of different substituents on the benzene ring of phenolic derivatives on this reaction.The result shows that a better conversion rate could be achieved through optimized experimental conditions with sodium methoxide as the catalyst,the catalyst feed quantity of 10%,the reaction temperature of 80℃,and the reaction time of 12 h.Moreover,these operating conditions was relatively cost-effective.
作者
孙洪飞
伍贤英
李国旺
補瑶
姚斌
沈雪
SUN Hongfei;WU Xianying;LI Guowang;BU Yao;YAO Bing;SHEN Xue(College of Environment and Resources,Chongqing Technology and Business University,Chongqing 400067,China;Chongqing Research Institute of Chemical Industry,Chongqing 400021,China)
出处
《应用化工》
北大核心
2026年第1期56-61,共6页
Applied Chemical Industry
基金
重庆市教育委员会科学技术研究项目(KJQN202400807)
重庆工商大学高层次人才科研启动项目(1956055)。
关键词
迈克尔加成反应
有机碱
反应条件优化
Michael Addition reaction
organic base
reaction condition optimization
