摘要
乳腺癌作为全球女性高发恶性肿瘤,其疾病负担持续增长。已有研究表明糖脂代谢指标水平的变化与乳腺癌发病风险之间存在密切关联,可通过介导慢性炎症状态、影响信号通路、促进氧化应激、影响性激素水平及其生物活性,以及驱动脂肪组织内分泌功能紊乱等关键生物学途径影响乳腺癌的发生与发展。此文通过系统综述糖脂代谢指标与乳腺癌发病风险的联系,旨在为深入研究糖脂代谢与乳腺癌的关系指明方向,为乳腺癌风险评估、早期诊断及防治策略的制定提供参考依据。
Breast cancer(BC)is a female malignant tumor with high incidence rate worldwide,and its disease burden continues to grow.Previous studies have demonstrated that there is a close association between changes of glucolipid metabolism indicators and risk of BC.Abnormal glucolipid metabolism may affect the occurrence and development of breast cancer by mediating chronic inflammatory states,affecting signaling pathways,promoting oxidative stress,affecting sex hormone levels and their biological activities,and driving endocrine dysfunction in adipose tissue.This paper systematically reviews the relationship between glucolipid metabolism indicators and risk of BC,aiming to point out the direction for further research on the relationship between glucolipid metabolism and BC,and to provide a reference basis for breast cancer risk assessment,early diagnosis,and prevention and treatment strategies.
作者
李丽春
邬昊
LI Lichun;WU Hao(Department of Outpatient,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China;Breast Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China)
出处
《公共卫生与预防医学》
2026年第2期136-140,共5页
Journal of Public Health and Preventive Medicine
基金
四川省科技计划项目(2018SZ0240)。
关键词
糖代谢
脂代谢
乳腺癌
发病风险
代谢综合征
Glucose metabolism
Lipid metabolism
Breast cancer
Onset risk
Metabolic syndrome
