摘要
目的探讨化疗过程中出现乙二胺四乙酸(EDTA)依赖性假性血小板减少症(EDTA-PTCP)的识别与鉴别,为医务人员及时诊断提供参考。方法分析1例乳腺癌患者接受紫杉醇脂质体化疗后出现血小板计数显著下降的病例。通过分析患者病史、用药情况及实验室检查结果,对EDTA-PTCP的发生机制及紫杉醇脂质体的关联性进行评价,并提出更换抗凝剂重新检测的诊断建议。结果经关联性分析,EDTA-PTCP发生可能与紫杉醇脂质体相关。更换抗凝剂重新检测后,患者血小板计数恢复正常,患者后续化疗方案未受影响,病情稳定。结论在化疗过程中出现血小板减少时,应及时考虑EDTA-PTCP可能性,通过外周血涂片或更换抗凝剂重新检测以明确诊断。
Objective To investigate the ways in which EDTA-dependent pseudothrombocytopenia(EDTA-PTCP)is identified and differentiated during chemotherapy in order to provide a reference for quick clinical diagnosis.Methods The clinical data of one breast cancer patient who experienced a significant decrease in platelet count after treatment with liposomal paclitaxel was analyzed.By reviewing the patient’s medical history,medications,and laboratory test results,the association between EDTA-PTCP and liposomal paclitaxel was studied,and recommendations for re-testing with alternative anticoagulants were proposed.Results The pharmacist assessed the likelihood of EDTA-PTCP associated with paclitaxel liposome.After replacement of the anticoagulant and retesting,the patient’s platelet count returned to normal.The patient’s subsequent chemotherapy plan was not affected,and the condition was stable.Conclusion In case of thrombocytopenia during chemotherapy,the possibility of EDTA-PTCP should be considered.Peripheral blood smears or retesting with a different anticoagulant should be adopted to confirm the diagnosis.
作者
吉柳
郝敏
武文慧
JI Liu;HAO Min;WU Wenhui(Department of Pharmacy,Dalian Women and Children’s Medical Center,Dalian Liaoning 116033,China)
出处
《中国药物警戒》
2026年第3期334-336,共3页
Chinese Journal of Pharmacovigilance
基金
2023年大连市市场监管事务服务中心委托项目(202312)。
