摘要
目的 探索血清淀粉样蛋白A(serum amyloid A,SAA)、C-反应蛋白(C-reactive protein,CRP)、癌胚抗原(carcinoembryonic antigen,CEA)在结肠癌诊断中的价值。方法 选取2023年10月—2024年10月在南华大学衡阳医学院附属第三医院就诊的98例疑似结肠癌患者为研究对象,患者均进行SAA、CRP、CEA检测,以病理检查结果作为金标准,分析单项检测和联合检测的诊断效能。结果 SAA、CRP单项检测结果与病理检查结果均为轻度一致(Kappa=0.283、0.301),CEA单项检测结果与病理检查结果中度一致(Kappa=0.418),联合检测结果与病理检查结果基本完全一致(Kappa=0.979)。SAA检测灵敏度、特异度、准确率为52.73%、76.74%、63.27%,CRP检测灵敏度、特异度、准确率为54.55%、76.74%、64.29%,CEA检测灵敏度、特异度、准确率为61.82%、81.40%、70.41%,联合检测灵敏度、特异度、准确率为100%、97.67%、98.98%,联合检测灵敏度、特异度、准确率均高于SAA、CRP、CEA单项检测,差异均有统计学意义(P <0.05)。病理检查阳性者的SAA、CRP、CEA水平分别为(17.99±2.65)ng/mL(16.25±2.05)mg/L、、(282.65±23.69)ng/mL,均高于阴性者的(5.44±1.65)ng/mL、(6.56±2.28)mg/L、(3.99±1.05)ng/mL,差异均有统计学意义(P <0.05)。结论 SAA、CRP、CEA联合检测运用在结直肠癌诊断中具有较高的诊断效能,为临床诊治提供参考。
Objective To explore the value of serum amyloid A(SAA),C-reactive protein(CRP),and carcinoembryonic antigen(CEA)in the diagnosis of colon cancer.Methods A total of 98 patients with suspected colon cancer who were admitted to the Third Affiliated Hospital,Hengyang Medical School,University of South China from October 2023 to October 2024 were selected.All patients underwent tests for SAA,CRP and CEA.Taking the pathological examination results as the gold standard,the diagnostic efficacy of individual tests and combined tests was analyzed.Results The individual test results of SAA and CRP were both moderately consistent with the pathological examination results(Kappa=0.283,0.301),while the individual test result of CEA was moderately consistent with the pathological examination results(Kappa=0.418).The combined test results were basically completely consistent with the pathological examination results(Kappa=0.979).The sensitivity,specificity,and accuracy of SAA detection were 52.73%,76.74%,and 63.27%respectively,those of CRP detection were 54.55%,76.74%,and 64.29%respectively,and those of CEA detection were 61.82%,81.40%,and 70.41%respectively.The sensitivity,specificity,and accuracy of the combined test were 100%,97.67%,and 98.98%respectively,which were all higher than those of the individual tests of SAA,CRP,and CEA.The differences were statistically significant(P<0.05).The levels of SAA,CRP,and CEA in positive cases of pathological examination were(17.99±2.65)ng/mL,(16.25±2.05)mg/L,and(282.65±23.69)ng/mL respectively,higher than those in negative cases,which were(5.44±1.65)ng/mL,(6.56±2.28)mg/L,and(3.99±1.05)ng/mL respectively,and the differences were statistically significant(P<0.05).Conclusion The combined detection of SAA,CRP and CEA has a high diagnostic efficacy in the diagnosis of colorectal cancer,providing a reference for clinical diagnosis and treatment.
作者
邹品衡
李伟才
ZOU Pinheng;LI Weicai(Department of Clinical Laboratory,the Third Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang Hunan 421900,China;Department of Emergency,the Third Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang Hunan 421900,China)
出处
《中国卫生标准管理》
2025年第23期115-118,共4页
China Health Standard Management
关键词
血清淀粉样蛋白A
C-反应蛋白
癌胚抗原
联合检测
结肠癌
诊断效能
serum amyloid A
C-reactive protein
carcinoembryonic antigen
combined detection
colorectal
diagnostic efficacy
