摘要
生育酚(Tocopherol)具有卓越的抗氧化效果,对防止老化有效果,但缺点是对光和UV敏感,稳定性低。为解决这一问题,利用纳米结构脂质载体(Nanostructured Lipid Carrier,NLC)的药物传达系统备受关注。NLC由固体和液体脂质组成,具有良好的药物包封率和稳定性,通过高压乳化技术(HPH)制备。本研究拟将生育酚包封在NLC中,进一步应用大分子凝胶(Carbogel),以提高其长期的理化稳定性。
Tocopherol is a powerful antioxidant effective in preventing aging,but it has the drawback of being sensitive to light and UV exposure,leading to stability issues.To address this,Reconstructed lipid carriers(NLC)have emerged as a promising trans dermal delivery system.NLC,composed of solid and liquid lipids,offer high drug encapsulation efficiency and improved stability,and they are typically prepared using high-pressure homogenization(HPH).This study aims to encapsulate tocopherol into NLC and further enhance its long-term physical and chemical stability by incorporating a polymer gel(Carbolic).
作者
李恩秀
王佑
金东寅
尹钟文
李画
丁相元
Lee Eunsu;Wang You;Kim Dongin;Yoon Jongmoon;Li Hua;Jung Sangwon(ANCORS Co.,Ltd.,Shanghai 201403,China)
出处
《广东化工》
2026年第3期35-39,48,共6页
Guangdong Chemical Industry
关键词
生育酚
胶体炭
纳米结构脂质载体
脂质和蛋白质屏障
长期稳定性增强
活性成分稳定剂
tocopherol
carbolic
Reconstructed Lipid Carrier(NLC)
Lipid&Protein Barrier
long-term stability enhancement
active ingredient stabilization
